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Yıl:2023; Cilt: 60; Sayı: 3>> Özet
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Nöropsikiyatri Arşivi; 2023;60(3):231-235
Şizofreni Hastalarında On Yıllık Kardiyovasküler Hastalık Riski ile Klinik Özellikler Arasındaki İlişki
Y Kapıcı , B Güc , A Tekin , S Abuş
Kahta Devlet Hastanesi, Adıyaman
Amaç: Kardiyovasküler hastalıklar (KVH), şizofreni hastalarında en önemli mortalite nedenlerinden biridir. Bu çalışmanın amacı, şizofreni hastalarında on yıllık KVH riski ve klinik belirtiler arasındaki ilişkiyi araştırmaktır. Yöntem: Araştırmanın örneklemini 208 şizofreni tanılı hasta oluşturmuştur. Şizofreninin belirti şiddetini değerlendirmek için her hastaya Pozitif ve Negatif Sendrom Ölçeği (PANSS) uygulandı. Şizofreni hastalarının 10 yıllık KVH riski QRISK*3 modeli ile hesaplandı. Bulgular: Hastaların 10 yıllık KVH riski %7,4 olarak saptandı. Hastaların ortalama sağlıklı kalp yaşı (QAGE) 53,1 idi. Şizofreni hastalarında hastalık süresi, vücut kitle indeksi ve negatif semptom şiddeti ile 10 yıllık KVH riski arasında pozitif korelasyon vardı (sırasıyla r=0,57, r=0,37 ve r=0,49). Şizofreni hastalarında hastalık süresi, vücut kitle indeksi ve negatif semptom şiddeti 10 yıllık KVH riski üzerinde yordayıcı etkiye sahipti (sırasıyla t=4,349 ve p<0,001; t=2,108 ve p<0,05; t=2,836 ve p<0,01). Sonuç: Bu çalışmanın bulguları, şizofreni hastalarında hastalık süresinin, negatif semptomların ve vücut kitle indeksinin artmış KVH riski için önemli bir risk faktörü olabileceğini göstermiştir.
The Relationship of Ten-Year Cardiovascular Disease Risk and Clinical Features in Patientswith Schizophrenia
Introduction: Cardiovascular diseases (CVD) are the one of the most important causes of mortality in patients with schizophrenia. This study aimed to investigate ten-year CVD risk and its relationship with clinical features in patients with schizophrenia. Methods: The sample of the study consisted of 208 patients with a diagnosis of schizophrenia. The Positive and Negative Syndrome Scale (PANSS) was administered to each patient to assess symptom severity of schizophrenia. The 10-year CVD risk of the participants was calculated with the QRISK*3 model. Results: 10-year CVD risk of the patients was found to be 7.4%. The mean healthy heart age (QAGE) of the patients was 53.1. Duration of disease, body mass index (BMI), and negative symptoms severity was positively correlated with 10-year CVD risk in patients with schizophrenia (r=0.57, r=0.37, and r=0.49, respectively). Duration of disease, BMI, and severity of negative symptoms predicted a 10-year CVD risk in patients with schizophrenia (t=4.349 and p<0.001; t=2.108 and p=0.037; t=2.836 and p=0.006 respectively). Conclusion: The findings of this study have shown that duration of disease, negative symptoms, and BMI may be important risk factors for increased CVD risk in patients with schizophrenia.

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