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Yıl:1994; Cilt: 31; Sayı: 2>> Özet
Nöropsikiyatri Arşivi; 1994;31(2):63-65
Konvülziyonlarla Seyreden Akut İzoniazid Zehirlenmesi
M Özmenoğlu, O Bölükbaşı, H Mocan, F Bulut
Karadeniz Technical University Medical School Farabi Hospital Department Neurology Clinics
lzoniazit halen en etkin antitüberküloz ajanlardan biridir, lzoniazit intoksikasyonu sıklıkla çocuklarda görülmekle birlikte literatürde bildirilen vaka sayısı 30 un üzerindedir. İzoniazid intihar amacıyla ya da kazayla yüksek dozda alındığında şiddetli konvülziyonlar ve nihayet komaya yol açabilir. Bu çalışmada, hiperglisemi, şiddetli konvülziyonlar ve komayla seyreden iki olgumuzu sunuyoruz.
Acute Isoniazid Poisoning Presenting As Seizures
Isoniazid is the most effective antituberculous agent yet available. Acute isoniazid poisoning .is common in children. More than 30 cases, to our knowledge, have been reported in the literature. Overdose of isoniazid, as in attempted suicide or accidentally may result in uncontrolable convulsions and coma. We report two cases of acute isoniazid intoxication presented with severe convursions, hyperglycemia and coma and treated with high dose of intravenous pyridoxine hydrochloride successfully.

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