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Yıl:2022; Cilt: 59; Sayı: 1>> Özet
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Nöropsikiyatri Arşivi; 2022;59(1):80-82
Elvitegravir/Kobisistat/Emtrisitabin/Tenofovir Alafenamid Kullanımına Bağlı Optik Nörit: Olgu Sunumu
T Acar, HA Eryılmaz, B Atılgan Acar, E Güçlü, O Karabay
Sakarya Üniversitesi, Sakarya
Primer insan immün yetmezlik virusu (HIV) ile enfekte kişilerde enfeksiyonun kendisi, fırsatçı enfeksiyonlar, malignite ya da vasküler nedenli nörooftalmik tutulum olabilir. Ancak tüm incelemelere rağmen herhangi bir etyolojik nedenin saptanmadığı antiretroviral tedavi (ART) alan hastalarda tedaviye bağlı optik nöropati düşünülebilir. Bu sunuda 20 yaşında HIV enfeksiyonu nedeniyle 4 aydır elvitegravir/kobisistat/ emtrisitabin/tenofovir alafenamid kullanan bir hastada optik nörit gelişmesi üzerine tedavi rejiminin tenofovir disoproksil + emtrisitabin ve lopinavir+ritonavir kombinasyonu ile değiştirilmesinden kısa süre vizyon kaybının tama yakın düzeldiği gözlendi. Bu hastalarda mevcut bulguların hızlıca tanınması ve gerekli değişikliğin uygulanması kalıcı hasarların önlenmesinde son derece önemlidir.
Optic Neuritis due to Use of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide: A Case Report
Neuroophthalmic involvement may occur in people infected with primary human immunodeficiency virus (HIV) due to the infection itself, opportunistic infections, malignancy or due to vascular causes. However, treatment-related optic neuropathy may be considered in patients receiving Antiretroviral therapy (ART), without an identified etiological cause, despite all examinations. In this case report, a nearcomplete recovery was observed in vision loss of a patient, whose 4-month treatment regimen of elvitegravir/cobicistat/emtricitabine/ tenofovir alafenamide (E/C/FTC/TAF) was replaced with a combination of tenofovir disoproxil + emtricitabine and lopinavir+ritonavir due to the development of optic neuritis. Recognition of the present symptoms rapidly and the implementation of the necessary change is extremely important for preventing permanent damage in these patients

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