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Yıl:2022; Cilt: 59; Sayı: 1>> Özet
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Nöropsikiyatri Arşivi; 2022;59(1):44-47
Fibromiyalji Hastalarında Nöropatik Ağrı ve Klinik Bulgularla İlişkisi
MS Akaltun, Ö Altındağ, A Akyol, H Göktürk, A Aydeniz, S Gürsoy, A Gür
Gaziantep Üniversitesi, Gaziantep
Amaç: Fibromiyalji Sendromu (FMS), kronik yaygın vücut ağrısı, yorgunluk ve hassas noktaların varlığı ile karakterize bir klinik durumdur. Bu çalışmada, FMS’nin bir tür nöropatik ağrı olabileceğini ve nöropatik ağrı ile uyku bozukluğu ve depresyon arasındaki ilişkiyi araştırdık. Ayrıca bu klinik durumlar ile hastalık şiddeti arasındaki ilişkiyi araştırdık. Yöntem: Çalışmaya 2010 ACR tanı kriterlerine göre FMS tanısı alan 76 hasta dâhil edildi. Hastalar Fibromiyalji Etki Anketi (FES), Hamilton Depresyon Derecelendirme Ölçeği (HAM-D), Pittsburgh Uyku Kalitesi İndeksi (PUKİ), Douleur Neuropathique 4 (DN4) ve Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) ölçekleri ile değerlendirildi. Bulgular: LANSS ölçeğine göre hastaların %92,1’inde ve DN4 ölçeğine göre %82,9’unda nöropatik ağrı vardı. Pittsburg Uyku Kalitesi Ölçeğine göre hastaların %90,8’inde uyku kalitesi düşüktü. HAM-D’ye göre hastaların %82,9’unda depresyon vardı. Hastaların ortalama FES değerleri 63,16±10,73 olarak hesaplandı. DN4 değerleri ile FES, PUKI, HAM-D ve LANSS arasında pozitif korelasyon vardı. LANSS değerleri ile FES ve PUKI değerleri arasında pozitif korelasyon vardı. Sonuç: Bu çalışmada FMS’de nöropatik ağrı sıklığının yüksek olduğunu bulduk. Ayrıca nöropatik ağrı skalaları ile depresyon, uyku bozukluğu ve fibromiyalji etki skoru arasında pozitif bir ilişki bulduk. Ağrı, işlevsellik ve psikososyal özellikler fibromiyaljiyi tam olarak anlamak için kapsamlı bir şekilde değerlendirilmelidir. Anormal ağrı süreci ve ikincil klinik durumlar birlikte düşünülmelidir.
Neuropathic Pain and Its Relationship with Clinical Findings in Patients with Fibromyalgia
Introduction: Fibromyalgia syndrome (FMS) is a clinical condition characterised by chronic generalised body pain, fatigue and presence of tender points. In this study, we hypothesized that FMS could be a type of neuropathic pain and investigated the relationship between neuropathic pain and sleep disturbance and depression. We also investigated the association between these clinical conditions and disease severity Methods: Seventy-six patients who had FMS diagnosis according to 2010 ACR criteria were included in the study. Patients were evaluated by Fibromyalgia Impact Questionnaire (FIQ), Hamilton Depression Rating Scale (HAM-D), Pittsburgh Sleep Quality Index (PSQI), Douleur Neuropathique 4 Questions (DN4) and Leeds Assessment of Neuropathic Symptoms and Signs (LANSS). Results: Patients had neuropathic pain in 92.1% of patients with LANSS and 82.9% of patients with DN4. According to the Pittsburg Sleep Quality Scale, 90.8% of patients had poor sleep quality. According to HAM-D, 82.9% of the patients had depression. The mean FIQ values of the patients were calculated as 63.16±10.73. There was a positive correlation between DN 4 values and FIQ, PSQI, HAM-D and LANSS. There was a positive correlation between LANSS values and FIQ and PSQI values. Conclusion: In this study we found the frequency of neuropathic pain to be high in FMS. We also found a positive association between neuropathic pain scales and depression, sleep disturbance, and fibromyalgia impact score. Pain, functionality and psychosocial characteristics should be assessed extensively to understand fibromyalgia completely. Abnormal pain process and secondary clinical conditions should be considered together.

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