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Yıl:2021; Cilt: 24; Sayı: 3>> Özet
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Klinik Psikiyatri Dergisi; 2021;24(3):420-426
Öyküsünde karbonmonoksit zehirlenmesi olan geç başlangıçlı psikotik bozukluk: Bir olgu sunumu
G Salihoğlu, Ç Hocaoğlu
Hopa Devlet Hastanesi, Artvin
Karbonmonoksit (CO) zehirlenmesi ciddi nöropsikiyatrik bozukluklara neden olabilir. Ancak, bu konuya literatürde yeterince ilgi gösterilmemiştir. Özellikle zehirlenmeden sonra uzun dönemde ortaya çıkan nöropsikiyatrik belirtilerin tanımı, tedavisi, klinik seyri tam olarak bilinmemektedir. Bugüne kadar yapılan çalışmalarda CO zehirlenmesini takiben yıllar sonra olgularda nörolojik belirtiler, bilişsel, duygudurum ve kişilik bozuklukları gözlemlenmiştir. Ancak, uzun vadeli nöropsikiyatrik bulguların etiyopatolojisi ile ilgili hipotezler konuyu tam olarak aydınlatamamıştır. Hastanın klinik semptomatolojisiyle ilgili olarak çevresel ve nörobiyolojik karmaşık faktörlerin etkileşimi uzun süreli nöropsikiyatrik bozuklukların ortaya çıkmasında bir risk faktörü oluşturabilir. Bu çalışmada kliniğimize geç başlangıçlı psikotik belirtiler ile başvuran, 15 yıl önce CO zehirlenmesi geçiren 45 yaşındaki kadın hasta literatür bulguları eşliğinde sunulmuştur. CO zehirlenmesi sonrası olgular için nöropsikiyatrik değerlendirme ve düzenli olarak nörogörüntüleme ile yakın bir takip planlanmalıdır. Tüm dünyada zehirlenmelere bağlı ölümlerin başında gelen CO zehirlenmesinin neden olduğu nöropsikiyatrik belirti ve bozuklukların tanı ve tedavisi önemlidir. Klinisyenler atipik özellikli ve geç başlangıçlı psikotik yakınmaları olan ve CO zehirlenmesi öyküsü olan olgularda tıbbi değerlendirmeler konusunda dikkatli olmalıdırlar.
Late-onset psychotic disorder with a history of carbon monoxide poisoning: A case report
Carbon monoxide (CO) poisoning can cause severe neuropsychiatric disorders. However, no sufficient attention has been paid to this issue in literature. The definition, treatment and clinical course of neuropsychiatric symptoms that occur especially after poisoning are not known exactly. In the studies conducted to date, neurological symptoms, cognitive, mood and personality disorders have been observed in the cases years after CO poisoning. However, the hypotheses regarding the etiopathology of long-term neuropsychiatric findings have not clarified the subject completely. The interaction of environmental and neurobiological complex factors related to the patient's clinical symptomatology may be a risk factor for the emergence of long-term neuropsychiatric disorders. In this study, a 45-year-old female patient who presented to our clinic with late-onset psychotic symptoms and suffered from CO poisoning 15 years ago is presented in the light of literature findings. After CO poisoning, a close follow-up with neuropsychiatric evaluation and regular neuroimaging should be planned. The diagnosis and treatment of neuropsychiatric symptoms and disorders caused by CO poisoning, which is the leading cause of intoxication-related deaths all over the world, is important. Clinicians should be careful about medical evaluations in patients with atypical features and late-onset psychotic complaints and a history of CO poisoning.

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