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Yıl:2021; Cilt: 24; Sayı: 3>> Özet
TAM METİN
Klinik Psikiyatri Dergisi; 2021;24(3):315-323
Esansiyel hipertansiyonlu hastalarda anksiyete ile serum ürotensin-II ve S100B seviyeleri arasındaki ilişki
A Kazğan, S Korkmaz, S Yıldız, H Korkmaz, S Telo, M Atmaca
Siverek Devlet Hastanesi, Şanlıurfa
Amaç: Hipertansiyonlu bireylerde anksiyete bulgularının ortaya çıkmasında hatta hastalığın klinik bulgularının şiddetlenmesinde oksidatif stresle ve endotel fonksiyonlarıyla ilişkili olan bazı biyokimyasal parametrelerin rolü olabilir. Çalışmamızda, esansiyel hipertansiyon hastalarının anksiyete düzeyleri araştırılarak, anksiyete şiddetinin oksidatif stres parametrelerinden olan Ürotensin-II ve S100B protein seviyeleri üzerindeki etkisinin incelenmesi amaçlanmıştır. Yöntem: Çalışmaya, kan basıncı ölçümleri sonrasında venöz kan örnekleri alınan ve Sosyodemografik ve Klinik Veri Formu, Beck Anksiyete Ölçeği (BAÖ), Beck Depresyon Ölçeği (BDÖ) ölçekleri uygulanan 153 hasta dahil edildi. EnzymeLinked Immunosorbent Assay (ELISA) yöntemi ile S100B ve Ürotensin-II düzeyleri ölçüldü. Bulgular: Depresyon ve anksiyete puanları ile sistolik kan basıncı arasında pozitif yönde bir korelasyon bulunmaktaydı (p=0.049, r= 0.160; p
The relationship between anxiety and serum Urotensin-II and S100B levels in patients with essential hypertension
Objective: In hypertensive people, some biochemical parameters that are associated with oxidative stress and endothelial functions may play a role in the manifestation of anxiety symptoms, and even in the intensification of clinical symptoms of the disease. The purpose of our correlative study is to examine the association between anxiety severity and levels of oxidative stress parameters of Urotensin-II and S100B protein in patients with essential hypertension. Method: A total of 153 patients, who have applied Sociodemographic and Clinical Data Form, Beck Anxiety Inventory (BAI), Beck Depression Inventory and venous blood samples were taken after blood pressure measurement. S100B and Urotensin-II levels were measured with Enzyme-Linked Immunosorbent Assay method. Results: A positive correlation was determined between depression and anxiety scores, and systolic blood pressure (p=0.049, r= 0.160; p

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