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Yıl:2021; Cilt: 24; Sayı: 2>> Özet
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Klinik Psikiyatri Dergisi; 2021;24(2):153-159
İskemi modifiye albumin: Yaygın anksiyete bozukluğu ve panik bozukluktaki genel metabolik risk için potansiyel bir belirteç
E Kabadayı Şahin, G Turan, S Neşelioğlu, Mİ Atagün
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Eğitim ve Araştırma Hastanesi, Ankara
Amaç: İskemi modifiye albümin (İMA), hipoksi, asidoz, inflamasyon, oksidatif stres sonucu üretilen modifiye bir albümin türüdür. Bu çalışmada, yeni tanı alan ve daha önce ilaç kullanmamış yaygın anksiyete bozukluğu (YAB) ve panik bozukluk (PB) hastalarında serum İMA düzeylerinin değerlendirilmesi amaçlanmıştır. Yöntem: Bu kesitsel çalışmaya, daha önce ilaç kullanmamış 23 YAB, 25 PB hastası ve 28 sağlıklı kontrol dahil edildi. Katılımcılar sosyodemografik veri formu, Beck Depresyon Ölçeği (BDÖ) ve Beck Anksiyete Ölçeği (BAÖ) ile değerlendirildi. Tüm katılımcıların serum İMA düzeyleri ve rutin biyokimyasal parametreleri ölçüldü. Bulgular: Katılımcıların yaş, cinsiyet, vücut kitle indeksi (VKİ) ve biyokimyasal belirteçleri açısından gruplar arasında istatistiksel olarak anlamlı fark yoktu (p> 0.05). Serum İMA düzeyleri YAB ve PB gruplarında sağlıklı kontrollere göre anlamlı olarak daha yüksekken (p
Ischemia modified albumin: A potential marker for global metabolic risk in generalized anxiety disorder and panic disorder
Objective: Ischemia modified albumin (IMA) is an altered type of albumin produced due to exposure to hypoxia, acidosis, inflammation, or oxidative stress. In this study, we aimed to evaluate the serum IMA levels in newly diagnosed and medication-naive generalized anxiety disorder (GAD) and panic disorder (PD) patients. Method: This cross-sectional study included medicationnaive 23 GAD, 25 PD patients, and 28 healthy controls. The participants were evaluated with a sociodemographic form, the Beck Depression Inventory (BDI), and the Beck Anxiety Inventory (BAI). Venous blood samples were collected from all participants, and IMA levels and routine biochemical parameters were measured. Results: There was no statistically significant difference between three groups in terms of age, gender, body mass index (BMI) and routine biochemical markers of the participants (p>0.05). The GAD and PD groups had significantly higher serum IMA levels than healthy controls (p

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