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Yıl:2021; Cilt: 58; Sayı: Suppl 1>> Özet
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Nöropsikiyatri Arşivi; 2021;58(Suppl 1):3-6
Klinik Psikoz Spektrumu Boyunca Semptomatik Remisyon: Tarihsel ve Kavramsal Bir Gözden Geçirme
T Binbay, C Ergül , J V Os
Dokuz Eylül Üniversitesi, İzmir
Amaç: Bu derlemede klinik psikozun tüm spektrumu dikkate alınarak semptomatik remisyonun tarihsel ve kavramsal bir genel görünümü sunulacaktır. Yöntem: Dil ve yıl sınırlaması gözetilmeksizin psikozda remisyonla ilgili tüm makaleler kapsanmıştır. Konuyla ilgili makaleler için PubMed’de bir tarama anahtarı kullanılmıştır. Konu dışındaki makaleleri saptamak için tüm özetler gözden geçirilmiştir. Geriye kalan makalelerden ise analizler için veri elde edilmiştir. Analizdeki değişkenler yayımlanma yılını, dilini, araştırmanın yapıldığı ülkeyi, makalenin tipini, araştırmanın ana konusunu ve ana araştırma hastalığını ve remisyon kriterlerine atıf yapılıp yapılmadığını içermiştir. Bulgular: Veri analizi en eskisi 1950’de yayımlanan 439 makaleye dayanmıştır. 2005’te yayımlanan Şizofrenide Remisyon Çalışma Grubu kriterleri bu alanda köklü bir etkide bulunmuştur. Bu kriterlerin kullanıma girmesi yayımlanan araştırma sayısını, remisyon araştırmalarının coğrafyasını ve makalelerin uzamını açık biçimde değiştirmiştir. 2005 sonrasında yayımlanan araştırma sayısı hızlıca artmış ve makalelerin temel dili İngilizce haline gelmiştir. Önerilen kriterler işlevsel remisyon oranını pek değiştirmemiştir. Son on yıl içindeki araştırmalar akut ve geçici psikotik bozukluklar ile süreğen durumlar dâhil olmak üzere diğer psikotik bozukluklarda remisyonla ilgili çok az bilgi sağlamıştır. Ayrıca son on yıl içinde remisyona dair kavramsal bir ortak görüş şekillenmiş olsa da çalışmalardaki heterojenlik azalmaktan oldukça uzaktır ve bu durum psikozda remisyonu derli toplu ele almayı zorlaştırmaktadır. Sonuç: Şizofrenide remisyonla ilgili çalışmalar 1950’lerde başlamış olmakla birlikte 2005 yılında yayımlanan kriterler tüm alanı değiştirmiştir. Ancak remisyon tartışmaları henüz şizofreni dışındaki psikotik tanılar için geçerli değildir ve kısıtlıdır.
Symptomatic Remission Along the Clinical Psychosis Spectrum: A Historical and Conceptual Review
Introduction: In this review, a historical and conceptual panorama of symptomatic remission will be provided with a focus on the whole clinical psychosis beyond schizophrenia. Methods: We included all published articles on remission in psychosis, without any restrictions regarding language or year. We used a string to detect relevant articles in PubMed. We reviewed the abstracts to exclude out of scope results. Then, we evaluated the remaining articles to extract data. Variables included year of publication, language of publication, country of origin, type of article, main topic of research, main disorder studied, and reference to remission criteria. Results: The final dataset included 439 citations which dates back to 1950. The Remission in Schizophrenia Working Group (RSWG) criteria which was proposed in 2005 had a major effect on remission research in schizophrenia. The RSWG criteria changed the yearly published numbers of research, the main land of remission research and the scope of the articles. After 2005, the number of publications rapidly increased, and English became the primary language of the articles. Beyond prominent clinical effect, the criteria did have little impact on functional remission in schizophrenia. And also research in the last decade provided very few information about remission in other clinical aspects of psychosis spectrum including acute, transient and chronic forms. Furthermore, although there has been a conceptual unity in the last decade the heterogeneity of the studies is still far from decreasing, which still blurs the efforts to evaluate remission in psychosis. Conclusion: Although studies on remission in schizophrenia started in the 1950s, the criteria published in 2005 changed the whole area. However, remission discussions are not yet valid for psychotic diagnoses other than schizophrenia and are limited.

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