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Yıl:2020; Cilt: 57; Sayı: 4>> Özet
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Nöropsikiyatri Arşivi; 2020;57(4):294-298
Obstruktif Uyku Apne Sendromlu Hastalarda REM Uyku Dönemindeki Apne-Hipopne İndeksi ve Oksijen Desaturasyonu ile Sabah Baş Ağrısı Arasındaki İlişki
G Koç, KM Metin, BD Akçay, Ö Karadaş, R Sayın, S Yetkin,
Gülhane Training and Research Hospital, Ankara
Amaç: Sabah baş ağrısı olan hastalarda, REM uyku periyodu azalmıştır, ancak fizyopatolojisi hakkında az bilgi mevcuttur. Oksijen desatürasyonunun, özellikle REM uyku dönemlerinde olmak üzere, sabah baş ağrısı olan hastalarda daha belirgin olabileceği hipotezi ile obstruktif uyku apne sendromlu hastaların polisomnografik kayıtları incelendi. Yöntem: Toplam 365 hasta (Grup 1) ve kontrol grubu olarak 103 birey (Grup 2) değerlendirildi. Gruplar arasında sabah baş ağrısı varlığı karşılaştırıldı, sabah baş ağrısı olup olmamasına göre gruplar kendi içlerinde ayrılarak uyku parametreleri açısından ayrıca karşılaştırıldı. Bulgular: Grup 1 içerisinde sabah baş ağrısı olan hastalarda REM dönemindeki apne-hipopne indeksi (26,7/saat, min-maks: 0–108,4/saat), sabah baş ağrısı olmayan gruba göre (17,8/saat, min-maks: 0–107,8/ saat) yüksek bulundu. REM dönemindeki ve toplam uyku zamanındaki minumum oksijen satürasyonu sabah baş ağrısı olan grupta (REM: %82, min-maks: %50–94; toplam: %79, min-maks: %50–97) sabah baş ağrısı olmayan gruba (REM: %84, min-maks: %50–93; toplam: %81, min-maks: %50–90) göre düşük bulundu. Sonuç: Bu çalışmada obstruktif uyku apne sendromlu hastalarda REM uyku dönemindeki yüksek apne hipopne indeksi ve düşük oksijen satürasyonunun sabah baş ağrısı ile ilişkili olduğu bulundu.
Relationship between Apnea-Hypopnea Index and Oxygen Desaturation in REM-Sleep Period and Morning Headache in Patients with Obstructive SleepApnea Syndrome
Introduction: In patients with morning headache, REM sleep period decreases though little is known about its physiopathology. We evaluate the polysomnographic records of obstructive sleep apnea syndrome (OSAS) patients with the hypothesis that oxygen desaturations may be a better determinant in patients with morning headache, especially those in REM sleep periods. Methods: Patient group (group 1) with a total of 361 patients with OSAS and the controls (group 2) with 107 healthy individuals were evaluated. The presence of morning headache was compared between the groups, and sleep parameters were correlated with morning headache. Results: In group 1, patients with OSAS and morning headache, apneahypopnea index in the REM sleep period (26.7/hour, min-max: 0–108.4/ hour) was higher than those in patients without morning headache (17.8/hour, min-max: 0–107.8/hour). The minimum oxygen saturation in REM sleep period and total sleep time (TST) was lower in patients with morning headache (REM sleep period: 82%, min-max: 50–94% ; TST: 79%, min-max: 50–97%) in compared to patients without morning headache (REM sleep period: 84%, min-max: 50–93% ; TST: 81%, minmax: 50–90%). Conclusion: Here we demonstrated that higher apnea-hypopnea index and lower oxygen saturation in REM sleep period were associated with morning headache in patients with obstructive sleep apnea syndrome.

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