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Yıl:2020; Cilt: 57; Sayı: 4>> Özet
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Nöropsikiyatri Arşivi; 2020;57(4):290-293
Parkinson Hastalığının Tedavisinde Kullanılan Tek Kanallı Derin Beyin Stimulasyonun Uzun Süreli Sonuçları
H Kaptan, H Ekmekçi
Dokuz Eylül Üniversitesi, İzmir
Amaç: Subtalamik çekirdeğin (STN) hedeflenmesi ve derin beyin uyarımı (DBS) elektrodun konumlandırılması için en uygun yöntem hâlâ tartışılmaktadır. Bu çalışmada, STN’yi hedeflemenin en uygun yolunu belirlemek için tek kanallı stimülasyonlar kullanılmıştır. Bulgular klinik kullanım için sentezlenmiştir. Bu çalışmada tek kanal kullanılarak uygulanan DBS’nin uzun dönem sonuçları sunulmuştur. Yöntem: 2010 ile 2017 yılları arasında Parkinson hastalığını tedavi etmek için STN-DBS uygulanan 15 hastanın geriye dönük olarak incelenmiştir. Hastalar preoperatif olarak incelenmiştir. Ameliyattan 2–7 yıl sonra rutin takipleri yapılmıştır. Bulgular: Tek kanal STN-DBS kullanılması ile iyi motor sonuçları ortaya çıkabilmektedir. Ayrıca, Birleşik Parkinson Hastalığı derecelendirme Ölçeği Skoru (UPDRS) değerinde hem ON hem de OFF döneminde daha yüksek iyileşme elde edilmiştir. Sonuç: Tek elektrod ile uygulanan STN-DBS diğer metodlarla da kombine edildiğinde güvenli bir işlem olarak ortaya çıkmaktadır.
Long-term Results for Single Channel-Guided Deep Brain Stimulation Used toTreat Parkinson’s Disease
Introduction: The optimal method for targeting the subthalamic nucleus (STN) and positioning the deep brain stimulation (DBS) electrode is still controversial. In this study, single channel-guided stimulations were used in order to determine the most proper way to target the STN. Findings were synthesised for use in clinical situations. This paper presents the long-term results of DBS applied using single-channel guidance. Methods: We retrospectively reviewed 15 patients who had undergone STN-DBS to treat Parkinson’s disease in-between 2010 and 2017. All patients were examined preoperatively, and they were routinely followed-up 2–7 years postoperatively. Results: The use of single-channel guidance resulted in better outcomes of motor complaints of Parkinson’s patients. Moreover, a significantly greater improvement in Unified Parkinson’s Disease Rating Scale Score (UPDRS) was achieved in either ON or OFF periods of patients. Conclusion: Single channel-guided STN-DBS is a safe procedure and it results in improved motor outcomes in advanced Parkinson’s Disease.

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