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Yıl:2020; Cilt: 57; Sayı: 2>> Özet
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Nöropsikiyatri Arşivi; 2020;57(2):89-92
Obsesif Kompulsif Bozukluk Tanısı Olan Hastalarda İnsula Hacmi ve Klinik Değişkenlerle İlişkisi
S Yıldız , K Uğur , İ Taşkent , M Atmaca
Tunceli Devlet Hastanesi, Tunceli
Amaç: Obsesif kompulsif bozukluğu olan hastalarda son yıllarda yapılan beyin görüntüleme çalışmaları, hastalığın belirleyici belirti ve bulgularıyla ilişkili anomalileri saptamaya yardımcı olmuştur. Bu çalışmanın amacı, obsesif kompulsif bozukluğun etyopatogenezini daha iyi anlamak için insula hacmindeki ve buna bağlı parametrelerdeki morfometrik değişiklikleri araştırmaktır. Yöntem: Çalışma süresince Fırat Üniversitesi Hastanesi Psikiyatri Anabilim Dalı’na başvuran ve yatarak ya da ayaktan tedavi gören, DSM-IV tanı ölçütlerine göre OKB tanısı almış ve çalışma ölçütlerine uyan 20 hasta ile 13 sağlıklı kontrol grubu çalışmaya dahil edilmiştir. Hastalara Sosyodemografik ve Klinik Veri Formu, Hamilton Depresyon Değerlendirme Ölçeği (HAM-D), Hamilton Anksiyete Değerlendirme Ölçeği (HAM-A), Yale-Brown Obsesyon Kompulsiyon Derecelendirme Ölçeği (Y-BOCS) ve SCID-I uygulanmıştır. Hasta ve kontrol grubunda manyetik rezonans görüntüleme (MRG) kullanılarak insulanın volümetrik ölçümleri gerçekleştirilmiştir. Bulgular: Obsesif Kompulsif Bozukluğu olan hastalar ile sağlıklı kontroller arasında insula volümleri açısından anlamlı düzeyde fark gözlenmemiştir. Sonuç: İnsulanın hem hastalığın patofizyolojisi hem de klinik seyri ile ilişkisinin olabileceği söylenebilir. Bu bölgenin fonksiyonel özelliklerini inceleyen görüntüleme teknikleri ve bilişsel işlevleri inceleyen testlerin birlikte ele alındığı çalışmaların daha önemli ve verimli sonuçlara ulaşılmasını sağlayabileceği düşünülmektedir.
Insula Volume in Patients Diagnosed with Obsessive Compulsive Disorder and its Relation with Clinical Variables
Introduction: Neuroimaging studies performed in recent years on patients with obsessive compulsive disorder have determined anomalies that are possibly associated with the determinant signs and symptoms of the disease. The purpose of this study is to investigate the morphometric changes in insula volume and related parameters in order to understand the etiopathogenesis of obsessive compulsive disorder better. Method: Throughout the study, 20 patients eligible for the study criteria, who were diagnosed with OCD according to DSM-5 diagnostic criteria and receiving inpatient or outpatient treatment after applying to Firat University Hospital Psychiatry Department, and 13 healthy subjects in the control group have been included in the study. Sociodemographic and Clinical Data Form, Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A), Yale-Brown Obsession Compulsive Scale (Y-BOCS) and SCID-I have been applied to the patients. Volumetric measurements were performed on the insula by using magnetic resonance imaging (MRI) in patient and control groups. Results: No significant difference was observed between patients with Obsessive Compulsive Disorder and healthy controls with regard to insula volume. Discussion: It may be stated that insula may be associated with both the pathophysiology and clinical course of the disease. It is suggested that studies considering the imaging methods examining the functional characteristics of this area and tests on cognitive functions together may lead to significant and efficient results.

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