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Yıl:2019; Cilt: 56; Sayı: 4>> Özet
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Nöropsikiyatri Arşivi; 2019;56(4):313-315
Klozapine Bağlı İnterstisyel Akciğer Hastalığı? Nadir Görülen Bir Advers Etki: Olgu Sunumu ve Literatür Taraması
KC Can , D Karnak , HD Özgüven
Ankara Üniversitesi, Ankara
Klozapin, tedaviye dirençli şizofreninin tedavisinde altın standart antipsikotik ilaçtır. Klinik etkinliğinin yanında, klozapin ile ilişkilendirilen sayısız yan etki bildirilmiştir. Lökopeni ve agranülositoz gibi bazı yan etkileri iyi bilinmesine rağmen, klozapin ile ilişkili bazı nadir yan etkiler hakkında yayımlanmış çok az veri bulunmaktadır. Bu nadir yan etkiler arasında klozapin ile indüklenmiş interstisyel akciğer hastalığı hakkında çok az şey bilinmektedir. Bu yazıda, bir klozapin ile indüklenmiş akciğer hastalığı vakasını klinik özellikleri ve literatür gözden geçirmesi ile beraber sunuyoruz
A Very Rare Adverse Effect of Clozapine, Clozapine-induced Interstitial Lung Disease: Case Report and Literature Review
Clozapine is the gold-standard antipsychotic agent for treatmentresistant schizophrenia. Yet with all its clinical efficacy, there are numerous adverse effects associated with clozapine. Although many, such as leucopenia and agranulocytosis, are well established, there is little published material on the drug’s rare adverse effects. Among these, very little is known about clozapine-induced interstitial lung disease. Here we present such a case. We focus on its clinical aspects and discuss its relationship to the extant literature.

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