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Yıl:2019; Cilt: 56; Sayı: 3>> Özet
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Nöropsikiyatri Arşivi; 2019;56(3):186-190
Madde Kullanımı Olan Olgularda HBsAg, Anti-HCV ve Anti-HIVSeroprevalansı: Retrospektif bir Değerlendirme
İ Altuğlu, S Tanyeri, A Zeytinoğlu, AE Altıntoprak
Ege Üniversitesi, İzmir,
Amaç: Madde kullanımı ve eşlik eden enfeksiyonlar önemli bir morbidite ve mortalite nedenidir. Madde kullanımının yüksek olduğu bölgelerde hepatit B virüsü (HBV), hepatit C virüsü (HCV) ve insan immun yetmezlik virüsü (HIV) gibi viral enfeksiyonların prevalansı yüksektir. Ülkemizde madde kullanımında bulaşıcı hastalıklar ile ilgili epidemiyolojik çalışmalar kısıtlıdır. Bu kesitsel ve retrospektif çalışmada temel olarak söz konusu hasta grubunda hepatit B yüzey antijeni (HBsAg), anti-HCV antikoru (anti-HCV) ve anti-HIV antikoru (anti-HIV) pozitifliklerinin sıklığının değerlendirilmesi amaçlanmıştır. İkincil olarak, damar içi madde kullanımı olan hastalarda HBsAg, anti-HCV ve anti-HIV parametrelerinin değerlendirilmesi hedeflenmiştir. Yöntem: Çalışmada, 2013–2017 tarihleri arasında, denetimli serbestlik (DS) uygulaması ile bir üniversite hastanesi bağımlılık polikliniğine başvuran olguların dosya verileri ve tıbbi mikrobiyoloji seroloji laboratuvarına viral parametrelerin rutin tetkiki için gönderilen kan örneklerinin test sonuçları retrospektif olarak değerlendirildi. Verilerin istatistiki analizi 20.0 IBM SPSS programı ile yapılarak anlamlılık eşiği p<0,001 olarak belirlendi. Bulgular: Çalışmaya alınan 4357 hastanın 94’ünde (%2,2) HBsAg pozitif, 4451 hastanın 27’sinde (%0,6) anti-HCV pozitif, 4464 hastanın 10’unda (%0,2) anti-HIV pozitif olarak saptandı. Hasta kayıtlarından elde edilen bilgilere göre, 17 hastanın damar içi madde kullanımı öyküsü olduğu belirlendi. Bu hastaların üçünde anti-HCV pozitif ve bir hastada anti-HIV pozitif olarak saptandı. Sonuç: Çalışmamızda elde edilen verilerde, damar içi madde kullanımı olanlarda artmış HCV ve HIV prevalansı saptanırken, damar dışı yollarla madde kullananlarda normal popülasyona göre farklılık gözlenmemiştir. Bu grubun çok dikkatli bir şekilde izlenmesi, farklı bölgelerdeki oranların belirlenerek ulusal verilerin oluşturulması, önleme programlarının geliştirilmesi açısından çok önemlidir.
HBsAg, Anti-HCV and Anti-HIV Seroprevalance Among Drug Users: a RetrospectiveAssessment
Introduction: Drug abuse and co-occurring infections are associated with significant morbidity and mortality. In regions with high rates of drug usage, infections like hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are highly prevalent. Epidemiological studies on HBV, HCV and HIV infections among users of illicit drugs are scarce in Turkey. The primary aim of this cross-sectional and retrospective study was to determine the hepatitis B surface antigen (HBsAg), anti-HCV antibody (anti-HCV) and anti-HIV antibody (anti-HIV) seroprevalences in drug users who applied to a psychiatric outpatient clinic of drug addiction of a university hospital. Secondarily, the assessment of HBsAg, anti-HCV and anti-HIV parameters among intravenous drug users was aimed. Methods: Serum samples of all patients on probation who applied to a psychiatric outpatient clinic of drug addiction of a university hospital between 2013–2017 and sent to the department of medical microbiology for routine serologic testing were included in the study. The serologic results were obtained retrospectively from laboratory records. For the statistical analysis of the data IBM SPSS 20.0 program was used. Results: Among the studied individuals, the ELISA results demonstrated the existence of HBsAg, anti-HCV and anti-HIV in 94 out of 4357 patients (2.2%), 27 out of 4451 patients (0.6%) and 10 (0.2%) out of 4464 patients, respectively. According to the records, 17 of the patients reported intravenous drug usage. Among this patient group, three patients were found to be anti-HCV positive and one patient was found to be anti-HIV positive. Conclusion: In our study, the prevalence of HCV and HIV was increased in patients with intravenous drug usage, whereas in non-intravenous drug users the prevalence is similar to the normal population. In order to plan prevention and harm reduction services for this high-risk population, more national data is needed on HBV, HCV and HIV rates among this group.

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