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Yıl:2019; Cilt: 56; Sayı: 3>> Özet
TAM METİN
Nöropsikiyatri Arşivi; 2019;56(3):182-185
Obstruktif Uyku Apnesi olan kişilerde tam kan parametrelerinin CPAP tedavisi ile ilişkisi
C Özdemir, S Sökücü, Ş Aydın, ST Önür, K Kara
Yedikule Training and Research Hospital, İstanbul,
Amaç: Daha önce yapılan birçok çalışmada, NLR ve PLR’nin obstruktif uyku apne hastalığında (OUAH) inflamasyonla ilişkili olduğu gösterilmiştir. NLR ve PLR düzeyini etkileyecek eşlik eden komorbid hastalığı olmayan ve orta-ağır OUAH tanısı ile sürekli pozitif havayolu basınç (CPAP) kullanımı gereken hastalarda üç aylık düzenli SHB tedavisinin NLR ve PLR üzerine etkisi araştırdık. Yöntem: Komorbiditesi olmayan orta-ağır OUAH tanılı hastalarda üç aylık CPAP tedavisi öncesi ve sonrasında tam kan parametreleri değerlendirildi. Bulgular: Yirmi dokuz hasta (18 [%62,1] erkek) çalışmaya dahil edildi. Ortalama vücut kitle indeksi (BMI) 34,85±5,75; AHI değeri 49,85±27,42; verilen CPAP basıncı 9,34±1,77 idi. Tedavi öncesi ve sonrası BMI değerinde istatistiksel fark saptanmadı. ESS istatistiksel anlamlı oranda düşse de (p=0,000), NLR, PLR, ve CRP (p>0,05) değerlerinde istatistiksel fark saptanmadı. MPV ve RDW değerlerinde tedavi sonrası istatistiksel fark saptandı (p=0,01; p<0,001). Sonuç: Komorbiditesi olmayan orta-ağır OUAH hastalarında NLR ve PLR değerleri CPAP tedavisi sonrasında değişmemektedir
Response of Blood Parameters to CPAP Treatment in Patients with ObstructiveSleep Apnea
Introduction: Many studies have evaluated the relationship between the NLR and PLR in patients with obstructive sleep apnea (OSA), and have shown that they are related to inflammation. We evaluated whether 3 months of continuous positive airway pressure (CPAP) treatment in patients with moderate to severe OSA without any comorbidities would affect the NLR and PLR values. Methods: Full blood count parameters were evaluated before and after 3 months of CPAP treatment in patients with a diagnosis of moderate to severe OSA without any comorbidities. Results: Twenty-nine patients (18 [62.1%] males) were enrolled. The mean body mass index (BMI) was 34.85±5.75 kg/m2, the apneahypopnea index score was 49.85±27.42, and CPAP was 9.34±1.77. No significant change in BMI was observed after the third month of treatment. Although the Epworth Sleepiness Scale (ESS) score decreased significantly (p=0.000), no changes were observed in the NLR, PLR, or C-reactive protein level (p>0.05). Mean platelet volume and red blood cell distribution width changed significantly after treatment (p=0.01; p<0.001). Conclusions: The NLR and PLR did not change after CPAP treatment in patients with moderate to severe OSA without any comorbidities.

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