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Yıl:2018; Cilt: 25; Sayı: 3>> Özet
TAM METİN
Çocuk ve Gençlik Ruh Sağlığı Dergisi; 2018;25(3):237-242
Fluoksetin Kullanan İki Ergen Olguda Tedaviye Düşük Doz Aripiprazol Eklenmesi Sonrası Gelişen Akut Distonik Reaksiyon
F Yaylacı, HÖ Erkuran
Tokat Ruh Sağlığı ve Hastalıkları Hastanesi, Tokat
Amaç: Akut distoni göz (okulojirik kriz), baş, boyun (tortikollis veya retrokollis), kol-bacak veya gövde kaslarının ola-ğan dışı ve uzun süreli kasılmasışeklinde tanımlanmaktadır. Nigrostriatal yoldaki dopamin blokajı akut distoni de dahil ekstrapiramidal yan etki riskini artırmaktadır. Reseptör bağlanma özelliklerindeki farklılıklar nedeniyle aripip-razol kullanımı ile ilaçların neden olduğu akut distoni riski daha azdır. Yazında nadir bir durum olan aripiprazol ve akut distoni arasındaki ilişki olgu sunumları ve çalışmalarla belirtilmiştir. Bu yazıda fl uoksetin kullanımı sırasında tedaviye eklenen aripiprazole bağlı akut distoni gelişen ve ilaç kesilmesini takiben belirtilerin hızla gerilediği iki ergen hastanın sunulması amaçlanmıştır.
Acute Dystonic Reaction Following Add-On Low Dose Aripiprazole to Ongoing Flu-Oxetine Treatment Of Two Adolescents
Acute dystonia has been identifi ed as abnormal and long- lasting contraction of eye (oculogyric crisis), head, neck (torticollis or retrocollis), arm-leg or trunk muscles. Dopaminergic blockade within the nigrostriatal pathway increase the risk of extrapyramidal side effects, including acute dystonia. Due to differences arising from its receptor- binding properties, aripiprazole has been linked to lower rates of drug- related acute dystonia, compared to other commonly used atypical antipsychotic drugs. Scarcely reported in relevant literature, there has been a few number of case stu-dies that describe the relationship between aripiprazole and acute dystonia. Through this case report, we have aimed to present the clinical courses of two adolescents who had developed acute dystonia upon low- dose add on aripipra-zole to their original treatment with fl uoxetine, where symptoms quickly dissolved following cessation of aripiprazole.

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