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Yıl:2019; Cilt: 56; Sayı: 1>> Özet
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Nöropsikiyatri Arşivi; 2019;56(1):71-74
Guillain-Barré Sendromu ve Varyantları: Klinik Seyir ve Prognostik Faktörler
F Bölükbaşı, G Ersen, A Gündüz, FK Savrun, S Yazıcı, N Uzun, MA Akalın, ME Kızıltan
İstanbul Universitesi Cerrahpaşa, İstanbul
Amaç: Üçüncü basamak hastaneye başvuran popülasyonda, GuillainBarré sendromu (GBS) ve varyantlarının, sıklık, klinik özellikleri, tıbbi tedavi seçenekleri ve son fonksiyonel durumlarını incelemeyi amaçladık. Yöntem: 1998–2013 yılları arasında akut enflamatuvar polinöropati tanısı alan tüm hastaların tıbbi kayıtları retrospektif olarak tarandı. Demografik, klinik ve laboratuvar bilgileri, tedavi seçenekleri ve düzelme oranları toplandı. Sonuçlar: Toplam 183 hasta çalışma kriterlerini karşıladı. Alttipler, tipik demiyelinizan form (n=102, %79,1), akut motor duysal aksonal formu (n=11, %8,5), akut motor aksonal formu (n=10, %7,8), Miller-Fisher sendromu (n=5, %3,9), saf duysal tip (n=1, %0,8) şeklindeydi. Diğer hastalarda tanı, kronik enflamatuvar demyelinizan polinöropati idi. Tedavi bilgilerine 70 hastada ulaşılabildi. Hastaların çoğu intravenöz immunoglobulin (IVIg) veya IVIg ve metilprednizolon kullanmıştı. Bir hasta ölmüş, sekiz hastada iyileşme olmamıştı ve diğerlerinde farklı derecelerde iyileşme olmuştu. Yorum: Farklı tedavi seçenekleri arasında fark görülmemiş olmakla birlikte metilprednizolon kullanan hastalarda yetersiz yanıt nedeniyle IVIg gereksinimi dikkat çekti. © All Right Reserved By NÖROPSİKİYATRİ
Guillain-Barré Syndrome and Its Variants: Clinical Course and Prognostic Factors
Conclusions: We did not observe major change of recovery between different treatment options, however, most of the patients using methylprednisolone required IVIg because of inadequate response.

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