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Yıl:2018; Cilt: 2; Sayı: 1>> Özet
TAM METİN
Current Addiction Research; 2018;2(1):22-26
Buprenorfin ve Benzodiazepin Beraber Kullanımı İle Ortaya Çıkan Solunum Depresyonu
H Kaya, Ö Kaya, S Paltun
Ankara Numune Eğitim ve Araştırma Hastanesi, Ankara
Buprenorfin tebainden elde edilen yarı sentetik bir opioiddir. Analjezik etki sağlamada ve opioid yerine koyma tedavisinde kullanılmaktadır. Türkiye’de 2010 yılından beri opioid yerine koyma tedavisi (OYT) amacıyla naloksonu da içeren preperatlar halinde bulunmaktadır (Suboxone® ). Bu yazıda benzodiazepin ve buprenorfin beraber kullanımı ile gelişen solunum depresyonu olgusu anlatılacak ve bu etkileşimin olası mekanizmaları tartışılacaktır.
Respiratory Depression caused by Buprenorphine and Benzodiazepine Use
Buprenorphine is a semi-synthetic opioid derived from thebaine. It is used for analgesic effect and opioid substitution therapy. In Turkey, buprenorphine and naloxone combination (Suboxone®) has been used in opioid substitution therapy since 2010. In this paper respiratory depression arising after buprenorphine use together with benzodiazepine will be told and possible mechanisms of this interaction will be discussed.

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