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Yıl:2000; Cilt: 1; Sayı: 2>> Özet
Bağımlılık Dergisi; 2000;1(2):69-71
Alkol Kötüye Kullanımı ve Depresyonun Koku Eşiği Üzerine Etkileri
O Çalıyurt, E Üçuktürk, E Karasin, E Abay
Amaç: Psikiyatrik bozuklukların etkileri ve bu bozuklukların sonuçları ile meydana gelen biyolojik değişiklikler daha önceki çalışmalarda çok kez bildirilmiştir. Depresyon ve alkol kötüye kullanımı da beyin kan dolaşımı ve merkezi sinir siteminde hasar meydana getirmektedir. Bu iki bozukluğun beyindeki koku duyusu merkezleri ve iletim yollarındaki olası etkilerinin değerlendirilmesi amaçlanmıştır.

Yöntem: Psikiyatrik bozukluklara bağlı olarak oluşan koku eşiği değişmeleri Zwaardemaker olfaktometresi kullanılarak değerlendirilmiştir. Değerlendirme her iki burun deliğinde ayrı ayrı yapılmıştır. Depresyon ve alkol kötüye kullanımı olan gruplardaki veriler sağlıklı kontrol grubu değerleri ile karşılaştırılmıştır.

Sonuçlar: Alkol grubunda daha fazla olmak üzere hem depresyon hem de alkol kötüye kullanımı olanlarda koku eşiğinde, kontrol grubuna göre yükselme saptanmıştır. Alkol grubundaki iki hasta dışında lateralizasyona rastlanmamıştır.

Tartışma: Sonuç olarak, bu çalışmaya alınan hastalarda, uzun süre alkol kullanımına ve depresyona bağlı olarak oluşan beyin dokusu harabiyeti ve merkezi sinir sistemindeki değişikliklerin yol açtığı koku eşiğindeki yükselmeler gösterilmiştir.
Effects of alcohol abuse and depression on olfactory treshold
Object: There are numerous studies showed that biological cahanges occur with effects and consequences of psychiatric disorders. Depression and alcohol abuse negatively change the brain blood flow and make damage in the central nervous system. To determine the potential effects of these two disorders on olfactory areas and connection pathways aimed in this study.

Method: Olfactory treshold changes measured by Zwaardemaker olfactometry apparatus. Measurement made in both two nostrils seperately. Data achieved from depression and alocohol abuse groups compared with normal control group.

Result: There was an elevation found in olfactory tresholds of both alcohol and depression patients. In alcohol group the elevation was the highest. There was no lateralisation found except two alcohol abused patients.

Discussion: Olfactory treshold elevations showed in this study. By the consequenses of brain damage and central nervous system changes in depression and alcohol abuse patients olfactory treshold seems to change and makes difficulties on olfaction.

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