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Yıl:2018; Cilt: 5; Sayı: 2>> Özet
TAM METİN
The Journal of Neurobehavioral Sciences; 2018;5(2):102-105
Probiyotiklerin Th17 Hücreleri Aracılığıyla Multipl Skleroz (Ms) Hastalığına Terapötik Etkileri
G Gürel, BA Arslan
Üsküdar Üniversitesi, İstanbul, Türkiye
MS’in hastaya özgü hastalık gelişimi ve ortaya çıkan semptomlar heterojenlik gösterdiğinden hastalığı teşhis etmek ve tedavi yöntemini bulmak oldukça zor olmaktadır. T lenfositler ve MS hastalarının MSS lezyonlarındaki ürünleri gibi bağışıklık hücrelerinin bolluğu, MS’in immün aracılı bir bozukluk olduğu görüşünü desteklemektedir. Th17 hücrelerinin EAE ve MS’in immünopatogenezinde önemli bir rol oynadığı görülmektedir. Th17 hücreleri Th1 ve Th2’den bağımsız bir hücre alt grubudur. Kararlı durumdaki Th17 hücreleri konakçı savunması için önemli olmasına rağmen patojenik Th17 hücreleri birçok hastalığın gelişiminde rol oynamaktadır. Th17 hücreleri IL-17 sitokinini salgılamasıyla bilinmektedir. IL-17 salgılayan hücreler MS ve diğer birçok hastalıkta tespit edilmiştir. Ayrıca MS hastalarından alınan beyin omurilik sıvısında IL-17 seviyesinin yüksek olduğu bulunmuştur. Probiyotik bakterilerin insan sağlığı açısından önemli olduğu ve terapötik özellikleri olduğu bilinmektedir. Yapılan çoğu çalışmada Th17 ilişkili hastalıklarda probiyotiklerin proinflamatuar IL-17 üretimini ve aktivasyonunu inhibe etme yeteneğine sahip olduğu düşünülmektedir.
Therapeutic Effects of Probiotics on Multiple Sclerosis (MS) Diseases via Th17 Cells
MS-specific disease progression and emerging symptoms are heterogeneous, it is difficult to diagnose and find treatment. The abundance of immune cells, such as products of T lymphocytes and MS patients with CNS lesions, supports the view that MS is an immunomodulatory disorder. Th17 cells appear to play an important role in the immunopathogenesis of EAE and MS. Th17 cells are a subset of cells independent of Th1 and Th2. Although the Th17 cells in steady state are important for host defense, pathogenic Th17 cells play a role in the development of many diseases. Th17 cells are known to secrete IL-17 cytokines. IL-17 secreting cells have been identified in MS and many other diseases. In addition, IL-17 levels were found to be high in cerebrospinal fluid from MS patients. Probiotic bacteria are known to be important in terms of human health and have therapeutic properties. Many studies have suggested that probiotics have the ability to inhibit proinflammatory IL-17 production and activation in Th17-related diseases.

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