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Yıl:2004; Cilt: 5; Sayı: 3>> Özet
TAM METİN
Anadolu Psikiyatri Dergisi; 2004;5(3):141-147
Şizofreni hastalarının bir yıllık izlem çalışması
T Amuk, NK Oğuzhanoğlu, F Ateşci
Pamukkale Üniversitesi Tıp Fakültesi Psikiyatri ABD, DENİZLİ
Amaç: Bu çalışmada, şizofreni hastalarında tipik ve atipik antipsikotiklerin klinik etki ve yan etkilerinin bir yıllık izlem
sonucunda karşılaştırılması amaçlanmıştır. Yöntem: Çalışma kapsamına DSM-IV kriterlerine göre şizofreni tanısı konmuş
17 erkek ve 19 kadın hasta alınmıştır. Tüm deneklere başlangıçta sosyodemografik bilgiler ve hastalık öyküsüne yönelik
özelliklerin soruşturulduğu yarı yapılandırılmış bir görüşme anketi uygulanmıştır. Klinik değerlendirme için tedaviden önce,
tedavinin 1., 6. ve 12. ayları sonunda Pozitif Belirtileri Değerlendirme Ölçeği (SAPS), Negatif Belirtileri Değerlendirme
Ölçeği (SANS), Kısa Psikiyatrik Değerlendirme Ölçeği (BPRS), Klinik Global İzlem Ölçeği (CGI) ve Ekstrapiramidal
Belirtileri Değerlendirme Ölçeği (EBDÖ) uygulanmıştır. Bulgular: Her iki grupta da 6. ayın sonunda psikotik belirtilerde
başlangıca göre anlamlı düzeyde bir iyileşme gözlendi. Başlangıca göre 12. ayın sonunda atipik antipsikotiklerle tedavi alan
grupta anlamlı düzeyde iyileşme gözlenirken, tipik antipsikotiklerle tedavi alan grupta anlamlı düzeyde iyileşme saptanmadı.
Sonuç: Bir yıllık izlem çalışmamız, hem klasik hem de atipik antipsikotiklerin şizofreni tedavisinde etkin olduğunu,
ancak atipik antipsikotiklerin bu tedavi süresinde daha etkin olduğunu gösterdi.
One [year] follow-up study in schizophrenic patients
Objective: In this study were aimed to compare the efficacy and side effect of typical and atypical antipsychotics in
patients with schizophrenia. Method: Seventeen male and nineteen female schizophrenic patients according to DSM-IV
criteria were included in the study. All subjects were given a sociodemographic questionnaire as well as a semistructured
interview concerning the features of the current and past psychiatric disorder. For clinical evaluation; before
treatment and at the end of the 1st, 6th and 12th [month]s Scale for the Assesment of Positive Symptoms (SAPS), Scale
for the Assesment of Negative Symptoms (SANS), Brief Psychiatric Rating Scale (BPRS), Clinical Global Impression
(CGI) and Extrapyramidal Symptom Rating Scale were applied all of the subjects. Results: Both of the two groups
showed a significant improvement at the end of six [month]s compared to beginning. On the other hand, the group treated
with atypical antipsychotics showed a significant improvement at the end of twelve [month]s compared to beginning but
the group treated with typical antipsychotics did not show a significant improvement at this period. Conclusions: This 1-
[year] follow-up study showed that both typical and atypical antipsychotics were effective in the treatment of schizophrenia but the efficacy of atypical antipsychotics were significantly greater than typical antipsychotics at the
treatment period.

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