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Yıl:1998; Cilt: 35; Sayı: 3-4>> Özet
Nöropsikiyatri Arşivi; 1998;35(3-4):144-150
Tourette Sendromu ve obsesif kompulsif bozuklukta işitsel olayla ilintili potansiyeller
S Zaimoğlu, MY Yazgan, S Karamürsel, M Devrim, AR Arman
Marmara Üniversitesi Tıp Fakültesi Psikiyatri Anabilim Dalı
Tourette Sendromu (TS) çocukluk döneminde başlayan, sıklıkla Obsesif Kompulsif Bozukluk (OKB) ve Dikkat Eksikliği Aşın Hareketlilik Bozukluğu (DEAHB) ile birlikte görülen nöropsikiya-trik bir bozukluktur. Tiklerle birlikte görülen OKB olgularının diğer OKB olgularından etiolojik olarak farklı olduğu düşünülmektedir. Sunulan iki çalışmada, yaşları 8-17 arasında olan TS, tiklerin eşlik ettiği ve etmediği OKB olgularında işitsel olayla ilintili potansiyelleri değerlendirdik. İlk çalışmanın bulguları TS tanısı alan çocukların erken dönemde hedef olmayan uyanları bastıramadıklannı ve onlara (normallere göre) daha fazla dikkat ettiklerini gösterdi. İkinci çalışmada, Pl (pozitif-1 ve standart N2 (negatif-2) yanıtlannın tiklerin eşlik ettiği ve etmediği OKB olgularının ayrımında önemli olduğunu bulduk. İki çalışmanın bulgulan olayla ilintili potansiyellerin, TS ve OKB'un nörobiyoloji-sine katkıda bulunan genetik ve sinir sistemi gelişimi ile ilgili etkenlerin tanımlanmasında yararlıı bir araç olduğunu vurgulamaktadır.
Auditory Event-Related Potentials In Tourettes Syndrome And Obsessive Compulsive Disorder
Tourette's syndrome CTS) is a chronic, chilhood onset neuropsychiatric disorder that is frequently comorbid with Obsessive Compulsive Disorder (OCD) and Attention Deficit Hyperactivity Disorder (ADHD). Tic-related early onset OCD is etiologically distinct from other OCD cases. Auditory event-related potentials were recorded in TS, tic-related and non-tic-related OCD cases aged between 8-17 [year]s in two separate studies. In the first study, TS children were unable to inhibit irrelevant signals and they paid more attention to standard stimuli than the normal children. In the second study, we observed PI (positive-1) and standard N2 (negative-2) responses critical for the distinction between tic-related and non-tic-related OCD cases. These find­ings suggest that the event-related potentials are useful for identifying genetic and neurodevelop-mental features in neurobiology of TS and OCD.

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