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Yıl:1999; Cilt: 36; Sayı: 1>> Özet
Nöropsikiyatri Arşivi; 1999;36(1):23-26
Bir intrakranyal granülositik sarkoma (kloroma) olgusu
E Tüzün, Y Krespi, R Tuncay, O Çoban, S Bahar
İ.Ü. istanbul Tıp Fak Nöroloji A. D.
Granülositik sarkoma (kloroma), genellikle akut miyeloblastik lösemi (AML) veya kronik miyeloid lö­semi (KML) seyrinde ortaya çıkan, miyelositer seri­ye ait farklı diferansiyasyon seviyelerindeki malign granülosit birikimi ile oluşan solid bir tümördür. Sıklıkla subperiostal kemik dokusu, deri, gastroin­testinal sistem ve lenf düğümlerinde saptanmakla beraber, seyrek olarak intrakranyal kloroma olgula­rı da bildirilmiştir.
Bu nedenle fokal nörolojik bulgularla başvuran lö­semi olgularında santral sinir sistemi infeksiyon, kanama, sekonder malignite ve meningeal yaydım komplikasyonlan gibi tanı olasılıkları arasında klo­roma da yer almalıdır.
Bu çalışmada mültipl intrakranyal granülositik sarkoma tanısıyla izlediğimiz bir AML olgusu bildi­rilecektir.
A Case of Intracranial Granulocytic Sarcoma(Chloroma)
Granulocytic sarcoma (chloroma) is a solid tumor of immature malign granulocytes at various levels of differentiation, usually occurring m patients with acute myeloblastic leukemia (AML) or chronic myelogenous leukemia (CML). Although it is most frequently detected in subperi­ostal bone tissue, skin, gastrointestinal system and lymph nodes, patients with intracranial granu­locytic sarcoma have also been reported. Chloroma must be considered in the differential diagnosis of leukemia patients presenting with focal ne­urologic findings together with infection, hemorrhage, secondary neoplasm and meningeal dissemination. We report a case of granulocytic sarcoma presen­ting as multiple intracranial massess.

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