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Yıl:2005; Cilt: 1; Sayı: 12>> Özet
Türkiye Klinikleri Dahili Tıp Bilimleri Dergisi Psikiyatri; 2005;1(12):58-66
Antipsikotik İlaçların Yan Etkileri
MC Saka, S Can, HD Özgüven, EC Atbaşoğlu
Ankara Üniversitesi Tıp Fakültesi Psikiyatri AD, ANKARA
Antipsikotikler (AP) psikotik bozuklukların tedavisinde ve hastaların hayat kalitesinde belirgin iyileşmeye yol açmakla birlikte önemli yan etkileri mevcuttur. Hareket bozukluklarının görülme sıklığı ikinci kuşak AP'lerin kullanıma girmesinden sonra bir miktar azalmıştır. Bununla birlikte, tanı ve müdahale, tedavi sürdürümü ve hastaların hayat kalitesi bakımından hala büyük önem taşımaktadır. Bu yazıda, akut distoni, parkinsonizm, akut akatizi, malign nöroleptik sendrom ve tardif diskinezi ile diğer tardif sendromlar tarif edilmiş, sebepleri, ele alınmaları ve tedavileri tartışılmıştır. Metabolik yan etkiler, özellikle son dönemde, ikinci kuşak AP kullanımının yaygınlaşması sonrasında önem kazanmıştır. Yazıda, kilo artışı, insüline direnç, hiperglisemi, DM, DKA, dislipidemi ile ikinci kuşak AP'lerin ilişkisi ve bu durumların ele alınması tartışılmıştır. Değinilen diğer yan etkiler, hiperprolaktinemi, antikolinerjik yan etkiler, alfa-1 blokajı ve ortostatik hipotansiyondur
Adverse Effects Of Antipsychotics
Although antipsychotics (AP) have provided a substantial improvement in the treatment of psychosis and well-being of patients, they have prominent adverse effects. The prevalence of movement disorders decreased with the advent of second generation AP, however, their diagnosis and management are still important issues in the context of patient compliance and quality of life. This article discusses the etiology and management of acute dystonia, parkinsonism, acute akathisia, malignant neuroleptic syndrome, tardive dyskinesia and other tardive syndromes. Secondly, the metabolic side effects of the second generation AP's are discussed as important issues in the long-term treatment: Weight gain, insulin resistance, hyperglycemia, diabetes mellitus, diabetic ketoacidosis, and dyslipidemia. Some of the other adverse effects alluded to are hyperprolactinemia, anticholinergic side effects, alfa-1 blokage and orthostatic hypotension.

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