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Yıl:2017; Cilt: 4; Sayı: 3>> Özet
TAM METİN
The Journal of Neurobehavioral Sciences; 2017;4(3):122-125
Bağımlılıkla ilişkili DRD2 RS1800497 polimorfizminin voleybolcular ve vücut geliştiricilerdeki dağılımları
İ Yüksel, S Kapıcı, C Sercan, H Kulaksız, T Polat, G Turan, K Ulucan
Üsküdar Üniversitesi, İstanbul
Günümüze kadar yapılmış olan araştırmalar, sporcuların genetik yapılarının atletik performanslarına olan katkılarını göstermiştir. Bu çalışmalar ile bilişsel yeteneklerin sporcuların atletik performanslarına etkilediğini ortaya koymasına rağmen, bilişsel yetenekler ve atletik performans ilişkisini ortaya koyan yeteri kadar genetik çalışma bulunmamaktadır. Bu çalışmamızda, beyin dopaminerjik sistemine ve atletik performansı üzerinde etkili olduğu bilinen dopamin reseptörü 2 rs1800497 polimorfizmini voleybol ve vücut geliştiricilerdeki bağlantısını araştırmayı amaçladık. Bu bağlamda, araştırmaya 9 kadın voleybolcu ve 15 aktif vücut geliştiricisi katılmıştır. Genotipleme için gerçek zamanlı PCR metodolojisi kullanılmıştır. Vücut geliştiricilerde A1A1, A1A2 ve A2A2 genotip ve frekansları sırasıyla 2 (13%), 1 (7%) ve12 (80%) olarak bulunmuştur. Çalışma grubumuzda ki tüm voleybol oyuncuları A2A2 genotipinde bulunmuştur. Çalışma grubumuzda bağımlılık ile ilişkili A1 allelinin voleybolcular ve vücut geliştiricilerinde daha az bulunduğu gözlemlenmiştir. Elde ettiğimiz sonuçlar, bizlere bilişsel sistemin atletik performans üzerine etkisinin poligenik veya multifaktöryel mekanizma ile açıklanabileceğini göstermiştir.
Addiction related DRD2 RS1800497 polymorphism distribution in volleyball players and bodybuilders
Studies to date have shown the contribution of an athletes’ genetic endowment in athletic performance. Although these studies revealed that cognitive abilities influence athletes’ competitive performance, there are only a few studies trying to investigate the association between genetic polymorphisms, which is associated with cognitive ability, and athletic performance. In the present study, we aimed investigate the link between dopamine receptor-2 (DRD2) gene rs1800497 polymorphism, which is known to exert influences on brain dopaminergic system and athletic performance of volleyball players and bodybuilders. In this regard, we enrolled 9 female volleyball players and 15 active bodybuilders in the study. Real-time PCR methodology was used for genotyping. The respective numbers and percentages of A1A1, A1A2 and A2A2 genotypes in bodybuilders were 2 (13%), 1 (7%) and 12 (80%). All the volleyball players had A2A2 genotypes. The results have revealed that addiction related A1 allele is underrepresented in volleyball players and bodybuilders. These first findings indicate that the polygenic or multifactorial mechanism may explain effect of cognitive abilities in athletes’ performance.

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