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Yıl:2004; Cilt: 14; Sayı: 2>> Özet
TAM METİN
Klinik Psikofarmakoloji Bülteni; 2004;14(2):61-67
Obsesif kompulsif bozuklukta elektroensefalografi bulguları
A Yaşan, F Gürgen
Diyarbakır Devlet Hastanesi Psikiyatri Kliniği, Diyarbakır
Amaç: Obsesif kompulsif bozukluğun (OKB) etiyolojisinde işlevsel beyin patolojisinin rolü, genellikle pozitron emisyon tomografisi (PET), bilgisayarlı tek foton emisyon tomografisi (SPECT) ve elektroensefalografi (EEG) ile tespit edilir. EEG’nin non-invaziv oluşu, kolay uygulanabilirli- ği ve ucuz olması önemli üstünlükleridir. Bu çalışmada OKB tanısı alan hasta grubu ile normal sağlıklı kontrol grubunun EEG bulgularının kar- şılaştırılması ve bu sonuca etkisi olabilecek çeşitli sosyodemografik ve klinik faktörlerin saptanması amaçlanmıştır.
Yöntem: Bu prospektif çalışmada, Temmuz-Aralık 2003 tarihleri arası nda psikiyatri polikliniğine başvuran ve DSM-IV ölçütlerine göre OKB tanısı alan 46 olgu değerlendirilmiş ve elde edilen EEG bulguları nörolojik ve psikiyatrik bir bozukluğu olmayan 46 sağlıklı kontrol grubu ile karşılaştırılmıştır. Tüm olgularda, aktivasyon yapılmadan, sadece istirahat halinde elde edilen standart EEG kayıtları değerlendirilmiştir.
Bulgular: OKB grubunda EEG anormalliği sıklığı %52.2, kontrol grubunda %13 idi (p<0.01). Tüm beta dalgaları dışlandığında OKB tanılı grupta EEG anormalliği oranı %30.5, kontrol grubunda ise %2.17 idi (p<0.01). OKB tanılı deneklerde en sık görülen EEG anormalliği, yavaş dalga, diken ve keskin dalga aktiviteleriydi. Bu EEG anormallikleri ço- ğunlukla sol frontal ve temporal loplarda lokalizeydi.
Sonuç: OKB tanılı olguların yaklaşık üçte birinde EEG anormalliğinin görülmesi, bu hastalarda beyindeki işlevsel anatominin etiyolojinin saptanmasında önemli rol üstlenebileceğini işaret etmektedir. Lokalizasyonun daha çok frontal ve temporal loplarda olması bu bölgelere ait detaylı çalışmaların yapılması gerektiğini düşündürmektedir. Ayrıca, OKB’daki EEG anormalliklerini etkileyen faktörlerin daha iyi anlaşılması için de ayrıntılı yeni çalışmalara ihtiyaç vardır.(
Electroencephalography findings in patients with obsessive compulsive disorder
Aim: The role of functional brain pathology in the etiology of obsessivecompulsive disorder (OCD) is often determined by proton emissiontomography (PET), single photon emission computerized tomography(SPECT) and electroencephalography (EEG). EEG has importantadvantages including non-invasiveness, feasibility and costeffectiveness. The aim of this study was to compare EEG findings ofOCD group with normal healthy controls and investigate the effects ofsome clinical and demographic factors in the OCD group on EEGfindings.Methods: In this prospective study, 46 patients were diagnosed asOCD according to DSM-IV criteria in a psychiatry clinic between July2003 and December 2003 were compared with forty-six normalhealthy control who did not have any neurological or psychiatricdisorders. Standard EEG recording was recorded only in the restingperiod without using any activation methods.Results: There was no significant difference between the patients andcontrol group regarding sex and age (p>0.05). EEG abnormalitieswere found in 52.2% of OCD group and 13% of the control group(p<0.01). When all beta-waves were excluded, EEG abnormalitieswere found in 30.5% of OCD patients and 2.17% of the control group(p<0.01). The most common abnormal EEG findings found in the OCDgroup were slow, spike and sharp wave activities. These EEG findingswere most commonly localized to left frontal and temporal lobe.Conclusion: The occurrence of EEG abnormality in one-third of OCDpatients suggests the importance of functional brain anatomy indetermining the etiology of OCD. Further detailed functional andelectroencalpholographic studies are required for the evaluation offrontal and temporal lobe in OCD patients as most EEG abnormalities were located in those lobes.

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