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Yıl:2002; Cilt: 12; Sayı: 1>> Özet
TAM METİN
Klinik Psikofarmakoloji Bülteni; 2002;12(1):31-36
Psikiyatrik bozuklukların tedavisinde farmakogenomik
E Abay, İ Ateş
Trakya Ü. Tıp Fak. Psikiyatri ABD, Edirne
Farmakogenomik ilaç tedavisine alınan yanıtın önceden tahmin edilebilmesi için genetik bilgiyi kullanan yeni bir alandır. Psikiyatrik bozuklukların patogenezinde rol oynayan ve ilaç tedavisine alınan yanıtı etkileyen genler son zamanlarda araştırmaların odağı haline gelmiş ve aday genler ve varyantları tanımlanmıştır. Hızla gelişmekte olan moleküler genetik teknikleri bu alandaki ilerlemeye katkıda bulunmaktadır. Günümüzde, psikiyatrik tedaviler deneme-yanılma esasına dayalı olarak ampirik şekilde uygulanmaktadır. Psikiyatrik tedavilerle ilgili farmakogenomik bilgi, bireyin genetik bilgisine göre en yararlı ilacı belirleyerek alınan sonuçları iyileştirecektir. Bu yazıda psikofarmakogenomik konusunda günümüze kadar elde edilen bilgiler gözden geçirilmiştir.
Pharmacogenomics in the treatment of psychiatric disorders
Pharmacogenomics is a young field which uses genetic information to predict drug treatment response. Genes that are involved in the pathogenesis of psychiatric disorders and that influence drug treatment response have been the focus of investigation recently and candidate genes and their variants have been identified. The rapidly developing molecular genetic techniques contributed the advance in this field. At present, psychiatric treatment is based on a trial-and-error paradigm and therefore practiced empirically. Pharmacogenomic knowledge of psychiatric treatments will improve outcome by determining most beneficial drug according to the individual's genetic information. Data to date on psychopharmacogenomics is reviewed in this article

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