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Yıl:2001; Cilt: 11; Sayı: 4>> Özet
TAM METİN
Klinik Psikofarmakoloji Bülteni; 2001;11(4):257-261
Olanzapin kullanımı ile birlikte görülen hipomani: Olgu sunumu
A Akdemir, H Türkçapar
SSK Ankara Eğitim Hastanesi Psikiyatri Kliniği
Bir atipik antipsikotik olan olanzapinin kullanımının ardından ortaya çıkan hipomani ve mani olguları bildirilmiştir. Bu yazıda olanzapin kullanımından sonra mani belirtileri ortaya çıkan altı olgu sunulmuştur. Olguların beşi paranoid şizofreni, biri de dezorganize şizofreni tanısıyla izlenmekte olan hastalardı. Hastalara antipsikotik olarak olanzapin başlandıktan sonra beş olguda tedavinin akut döneminde, bir olguda ise kronik döneminde manik belirtiler gözlendi. Olanzapinin duygudurum üzerine olası etkileri ilacın etki mekanizması dikkate alınarak son literatür verileri ışığında tartışılmıştır
Hypomania with olanzapine use: Case reports
After administration of olanzapine, an atypical antipsychotic agent, several cases of olanzapine induced hypomania and mania have been reported. In this case report, we presented six cases of manic symptoms following olanzapine treatment. Five of the patients were diagnosed as paranoid schizophrenia, one of whom was diagnosed with disorganized type of schizophrenia. In five patients, manic symptoms were observed in the acute period of the treatmentand in one patient, manic symptoms appeared in the chronic period. The possible effects of olanzapine on moods are discussed in light of recent literature regarding the mechanism of action of this drug.

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