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Yıl:1992; Cilt: 3; Sayı: 1>> Özet
Türk Psikiyatri Dergisi; 1992;3(1):31-34
Pozitif ve Negatif Belirtili Şizofreni ve Kreatin Fosfokinaz
ME Önder, H Fidaner, V Bitlis, AR Şahin
Bu çalışmada bir grup (n= 62) şizofreni tanısı almış hastanın pozitif ve negatif belirti puanlarıyla serum kreatin fosfokinaz düzeyleri arasında bir ilişki olup olmadığı araştırıldı. Pozitif belirtilerle serum CPK düzeyleri arasında pozitif ve güçlü bir ilişki olmasına karşın, negatif belirtilerle serum CPK değerleri arasında zayıf ve negatif bir ilişki bulundu. Bu sonuçları iki yeni varsayımla yorumladık: (i) Bu ilişkiler pozitif/negatif belirtilerin hastaları sınıflandırma özelliklerinden kaynaklanmaktadır veya (ii) Yüksek serum CPK düzeyleri sadece yüksek pozitif belirti puanları ile ilişkilidir. Yeni çalışmalar bu varsayımları açıklığa kavuşturacaktır.

Creatine Phosphokinase in Schizophrenia with Positive and Negative Symptoms
In this study, we have investigated the relationship between serum creatine phosphokinase (CPK) level and positive or negative symptom scores in a group of schizophrenic patients (n=62). We found a signitificant direct correlation between positive symptoms and serum CPK level. We have interpreted these results by two new hypothesis: (i) these relations were derived from definition problems of positive/ negative symptoms or (ii) high serum CPK levels were only related with highly positive symptom scores. New researches will clarify these my pothesis.

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