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Yıl:1994; Cilt: 5; Sayı: 1>> Özet
Türk Psikiyatri Dergisi; 1994;5(1):52-56
Negatif ve Pozitif Belirtili Şizofren Hastalarda Bazal Kortizol Düzeylerinin Karşılaştırılması
R ÖZCANKAYA, İ KIRPINAR
Şizofrenik bozukluğun değişkenliği psikiyatride uzun süredir ilgi çeken konulardan biri olmuştur. Bu nedenle; farklı oluş nedeni, süreç ve tedavi yanıtlarıyla seyreden durumların belirlenmesine yönelik çalışmalar gerçekleştirilmiştir. Negatif, pozitif ve karışık şizofrenilerin biyolojik farklarıyla ilgili araştırmalar son zamanlarda gittikçe artmaktadır. Biz bu çalışmada limbik sistem-hipotalamus-hipofiz-böbrek üstü bezi ekseninin göstergelerinden biri olan bazal serum kortizol düzeyleri yönünden negatif ve pozitif şizofrenleri karşılaştırdık. Bazal serum kortizol düzeylerinin negatif şizofrenlerde pozitif şizofrenlere göre anlamlı derecede düşük olduğunu bulduk.

The Comparison of Basal Plasma Cortisol Levels of Schizophrenic Patients with Negative and Positive Symptoms
In recent [year]s, biological differences of negative, positive and mixed types of schizophrenia have been increasingly investigated. In this study basal serum cortisol levels indicator of limbic-hypothalamo -hypophyseal-adrenal (LHHA) axis, were compared in negative and positive schizophrenia. Basal serum cortisol levels were found to be significantly lower in negative schizophrenics than in positive schizophrenics.

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