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Yıl:2017; Cilt: 20; Sayı: 3>> Özet
TAM METİN
Klinik Psikiyatri Dergisi; 2017;20(3):227-237
Psikiyatrik Hastalıklar ve Göz: Optik Koherens Tomografinin Psikiyatride Yeri
AS Karadağ, A Kalenderoğlu
Adıyaman Üniversitesi, Adıyaman
Optik koherens tomografi (OKT); biyolojik doku katmanlarını, yüksek çözünürlükte tomografik kesitler alarak görüntüleyen, yeni bir tıbbi görüntüleme yöntemidir. Dokulara gönderilen ve farklı doku katmanlarından geri yansıyan ~800 nm dalga boyundaki infrared ışığın yansıma gecikme zamanını ve şiddetini ölçerek, dokuların ve patolojilerinin ultasonografiye benzer bir şekilde ama ondan çok daha yüksek çözünürlükte (1-15 mikron (µm)) kesit görüntülerinin alınmasına olanak tanır. OKT tekniği ilk olarak, Massachusettes Teknoloji Enstitüsü’nde (MIT) fizik profesörü Fujimoto ve ekibi tarafından tanımlanmıştır. Daha sonra oftalmoloji ve nörolojide kullanımı tanımlanmıştır. Özellikle bugünün OKT teknolojisinde çözünürlüğü artırılmış ve retinanın diğer tabakalarından, ganglion hücre kompleksini (GHT) (RSLT, GHT,IPT) farklılaştırmak mümkündür. OKT ile ölçülebilen diğer bir yapıda koroid kalınlıktır. Koroid insan vücudundaki en çok vaskülarizasyona sahip dokulardan biri olup dış retinanın oksijenizasyon ve beslenmesinde, retinanın ısı regülasyonunda, retinanın pozisyonel durumunda, retinal artık maddelerin uzaklaştırılmasında ve büyüme faktörlerinin salgılanmasında önemli görevler üstlenir. Yani damarsal ya da kan akımını etkileyen patolojilerde koroid yapısında incelme gözlenir. Psikiyatride OKT ‘nin kullanımı nispeten yenidir ve çok az çalışma yapılmıştır. Bu çalışmalarda aynı zamanda heterojen sonuçlar vermiştir. Bu derlemede bizim amacımız “beynin bir penceresi olarak” retinanın rolunünü OKT yöntemi ile açığa kavuşturmak, ayrıca, psikiyatrik bozukluğu dejeneratif bileşenlerini tanınmasını, psikiyatrik bozukluğu olan popülasyonunda OKT’nin olası uygulamalarını tartışmaktır.
Psychiatric Disorders and Eye: Optical Coherent Tomography in Psychiatry Aspect
Optic coherence tomography is a novel imaging method which can demonstrate biological tissue layers by getting high resolution sections. This technique measures delay time and intensity of ~800 nm wavelenght infrared light which is transmitted to and reflected from different tissue layers. It gives cross sectional images of tissues similar to but with much higher resolution (1-15 µm) than ultrasonography. OCT method was first described by Fujimoto et al from Massachusettes Institue of Technology. Then its use in ophthalmology and in neurology were described. Especially with today’s OCT technology resolution is enhanced and differentiating ganglion cell komplex (GCC) (RNFL, GCL, IPL) from other parts of retina is now possible. Another parameter that can be measured with OCT is choroidal thickness. Choroid is among the most vascularized tissues in human body and it has important roles in oxygenization and nutrition of outer retina, temperature regulation of the retina, arrangement of the position of retina, disposition of waste products from retina, and release of growth factors. Thus, any vascular pathology can cause choroidal thinning. Psychiatric use of OCT is relatively new, and few studies have been performed. This studies have also yielded heterogeneous results. Our aim this review elucidates the method of OCT and the retina’s role as a “window to the brain”. Furthermore, in delineating the degenerative components of psychiatric disorder, we discuss the possible applications of OCT in the psychiatric disorder population.

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