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Yıl:2017; Cilt: 54; Sayı: 2>> Özet
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Nöropsikiyatri Arşivi; 2017;54(2):187-188
Otizmli Bir Çocukta Risperidon Tedavisi ile Artan Hiperakuzi
AS Adanır, ÖG Çoban, E Özatalay
Akdeniz Üniversitesi, Antalya
Otistik spektrum bozuklukları, sosyal etkileşim ve iletişim becerilerinde kalitatif bozulma ile karakterize nörogelişimsel bozukluklardır. Bu temel özelliklere ek olarak, hiperakuzi gibi duyusal işleme anomalileri de sıklıkla bildirilmektedir. İşitsel hipersensitivitenin nedeni belirli olmamakla birlikte, inhibitör nöron disfonksiyonu ya da sensorial yolaklardaki anomaliler ile ilişkili olduğu düşünülmektedir. Ancak şu ana kadar ilaçlarla ilişkisi yeterince belirlenememiştir. Literatürde konu ile ilgili tek bir vaka olup, 5 yaşında otistik bir kız hastada risperidon tedavisi ile kötüleşen hiperakuzi bildirilmiştir. Biz de risperidon tedavisi ile hiperakuzi yakınması artan, ilaca ara verilmesi ile azalan ve ilaç tekrar başlandıktan sonra tekrar artan ve hiperakuzinin arttığı dönemlerde işlevselliğinde belirgin bozulma olan 11 yaşında otistik bir hastayı sunuyoruz. İşitsel hipersensitivenin otistik hastalarda olgumuza benzer şekilde günlük hayatını olumsuz etkilediği ve davranım bozukluğu ile ilişkili olduğu bilinse de; etyolojisi, tedavisi ve ilişkili olduğu durumlar ile ilgili bilinenler çok sınırlı olup, bu konuda yapılacak ileri çalışmalara ihtiyaç vardır.
Increased Hyperacusis with Risperidone in an Autistic Child
Autistic spectrum disorder is a neurodevelopmental disorder characterized by qualitative impairment in social interactions and communication skills. In addition to these core features, sensory processing abnormalities such as auditory hypersensitivity have been frequently reported. Although the cause of auditory hypersensitivity remains unknown, it is thought to be associated with decreased inhibitory processing, possibly resulting from an abnormal sensory gating system or dysfunction of inhibitory interneurons. Its relation to drugs has not been well documented to date. In the literature, there is only one case on hyperacusis that worsened with risperidone in a 5-year-old girl with autism. Here we represent the case of an 11-year-old boy with autism, in whom hyperacusis worsened with risperidone, decreased after the discontinuation of the medication, and re-occurred after the prescription of the drug again. Although auditory hypersensitivity tends to affect the child’s daily life negatively and is found to be correlated with behavioral problems in autistic patients, we still know very little about its etiology, treatment, and conditions related to it. There is a great need for conducting further studies in this regard.

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