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Yıl:2017; Cilt: 54; Sayı: 2>> Özet
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Nöropsikiyatri Arşivi; 2017;54(2):168-174
Nöroloji Yoğun Bakım Ünitesinde Bilinç Değişikliği Nedeni ile İzlenen Hastaların Devamlı EEG Monitorizasyonunda Saptanan Elektroensefalografik Paternler
E Altındağ, ZV Okudan, ST Özkan, Y Krespi, B Baykan
¹İstanbul Florence Nightingale Hastanesi, İstanbul
Amaç: Çalışmamızda bilinç değişikliği ile izlenen hastalarda devamlı EEG monitorizasyonuyla (dEEG) saptanan çeşitli elektrografik paternlerin (periyodik deşarj (PD), repetetif diken dalga (RDD), ritmik delta aktivitesi (RDA), nonkonvülzif nöbet (NKN) ve nonkonvülzif status epileptikus (NKSE) sıklığı ve bu önemli paternlere eşlik eden klinik ve laboratuvar bulgularının araştırılması amaçlandı. Yöntem: İki yıl süre ile nöroloji yoğun bakım ünitesinde (NYBÜ) bilinç değişikliği nedeniyle yatırılmış, dEEG monitorizasyonu yapılmış ardışık hastaların klinik, elektrofizyolojik, radyolojik ve laboratuvar bulguları retrospektif olarak değerlendirildi. Bulgular: Ortalama yaşı 68,2 olan, 25’i erkek 57 hasta çalışmaya alındı. dEEG monitorizasyon süresi ortalama 2532,6 dakikaydı. Monitorizasyonda en sık görülen paternler PD (%33) ve NKN-NKSE’di (%26,3). NKN-NKSE varlığının PD ile ilişkili olduğu (%57,9, p<0,001) görüldü. PD ve NKN-NKSE en sık akut iskemik serebrovasküler hastalık ve hipoksik anoksik ensefalopatili hastalarda saptandı. PD ve NKN-NKSE saptanan grupta monitorizasyon süresi daha uzundu (p:0,004, p:0,014). Monitorizasyon öncesi EEG’de herhangi bir elektrografik patern saptanması monitorizasyonda herhangi bir elektrografik patern varlığıyla ilişkiliydi (%59,3, p<0,0001). Elektrografik patern saptanan hastalarda monitorizasyon sırasında konvülzif veya NKN görülmesi daha sıktı (p<0,0001). NKN-NKSE’nin %66,7’si ilk 12 saat, %26,7’si 12-24 saat içinde izlendi. Sonuç: Çalışmamızın sonucunda primer beyin hasarlanmasına bağlı bilinç değişikliği nedeni ile NYBÜ’ne yatırılan, monitorizasyon öncesi EEG incelemesinde herhangi bir elektrografik patern (PD veya NKN, NKSE) saptanan hastaların klinik ve/veya elektrografik nöbet veya PD saptanması açısından en az 24 saat monitorize edilmesi gerektiği sonucuna varıldı.
Electroencephalographic Patterns Recorded by Continuous EEG Monitoring in Patients with Change of Consciousness in the Neurological Intensive Care Unit
Introduction: Our aim was to examine the frequency of various electrographic patterns including periodic discharges (PD), repetitive spike waves (RSW), rhythmic delta activities (RDA), nonconvulsive seizures (NCS) and nonconvulsive status epilepticus (NCSE) in continuous EEG monitoring (cEEG) of the critically ill patients with change of consciousness and the presence of specific clinical and laboratory findings associated with these important patterns in this study. Methods: Patients with changes of consciousness in the neurological intensive care unit (NICU) were consecutively monitored with cEEG during 2 years. Their clinical, electrophysiological, radiological and laboratory findings were evaluated retrospectively. Results: This sample consisted of 57 (25 men) patients with a mean age of 68.2 years. Mean duration of cEEG monitoring was 2532.6 minutes. The most common electrographic patterns were PD (33%) and NCS-NCSE (26.3%). The presence of NCS-NCSE was significantly associated with PD (57.9%, p<0.001). PD and NCS-NCSE were the mostly seen in patients with acute stroke and hypoxic encephalopathy. Duration of monitoring was significantly longer in the group with PD and NCS-NCSE (p:0.004, p:0.014). Detection of any electrographic pattern in EEG before monitoring was associated with the presence of any pattern in cEEG (59.3%, p<0.0001). Convulsive or nonconvulsive seizure during monitoring was common in patients with electrographic patterns (p<0.0001). 66.7% of NCS-NCSE was seen within the first 12 hours and 26.7% was seen within the 12-24 hours of the monitoring. Conclusion: Detection of any electrographic pattern in EEG before monitoring was associated with the presence of any important pattern in cEEG monitoring. This association suggest that at least 24 hours-monitoring of these patients could be useful for the diagnosis of clinical and/or electrographic seizures.

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