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Yıl:2017; Cilt: 18; Sayı: 2>> Özet
TAM METİN
Anadolu Psikiyatri Dergisi; 2017;18(2):179-183
Antidepresan kullanan psikiyatrik hastalarda metabolik sendrom sıklığı
E Fındıklı, F İzci, MA Camkurt, A Çetinkaya, HA Fındıklı, M Atmaca
Sütçüimam Üniversitesi, Kahramanmaraş
Amaç: Antidepresan kullanan hastalarda metabolik sendrom (MS) varlığını araştıran çalışma sayısı kısıtlıdır. Bu çalışma ile polikliniğe başvuran ve çeşitli antidepresan kullanan psikiyatrik hastalarda MS ve ilişkili faktörlerin oranlarını araştırmak ve karşılaştırmak amaçlanmıştır. Yöntem: Çalışma fluoksetin, paroksetin, sertralin, citalopram, essitalopram, klomipramin, venlafaksin kullanan 18-60 yaş arası depresif ve anksiyete bozukluğuna sahip 70 hastadan oluşmuştur. Çalışma ölçütlerine uyan hastaların açlık kan şekerleri, kan trigliserit ve kolesterol düzeyleri, ortalama kan basıncı, vücut kitle indeksi, bel çevresi ve Ulusal Kolesterol Eğitim Programı – Erişkin Tedavi Paneli III’e göre (NCEP-III) MS oranları tespit edildi. Sonuç: NCEP-III’e göre tüm hastalardaki MS sıklığı %32,8 idi. En yüksek metabolik sendrom oranları klomipramin, paroksetin ve venlafaksin gruplarında saptandı. Fluoksetin grubu metabolik sendrom açısından en güvenli ilaç olarak saptandı. Tartışma: Klasik antidepresanlar metabolik senrom oranlarını artırmaktadır ve bu da psikiyatrik hastaların mortalite, morbidite ve yaşam kalitesini etkilemesi açısından oldukça önemlidir.
The frequency of metabolic syndrome in psychiatric patients using antidepressant medications
Objective: There are limited studies investigating the metabolic syndrome (MS) in patients using antidepressants. This study examines and compares the prevalence of MS and related factors in psychiatric patients taking various antidepressants at an outpatient clinic. Methods: The study comprised a total of 70 patients using fluoxetine, paroxetine, sertralin, citalopram, essitalopram, clomipramine and venlafaxine aged 18- 60 years with depressive and anxiety disorder. MS rates of patients (according to National Cholesterol Education Program-Adult Treatment Panel III-(NCEP III)) who met the study criteria were obtained. Results: In our study metabolic syndrome frequency was 32.8% in total patient groups according to NCEP-III criteria. The higher metabolic syndrome frequency was found in drug groups such as clomipramine, paroxetine and venlafaxine groups. The safest drug for metabolic syndrome was fluoxetine as seen in its relevant group. Conclusion: Conventional antidepressants may cause metabolic syndrome which is important for mortality, morbidity and quality of life of psychiatric patients.

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