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Yıl:2017; Cilt: 3; Sayı: 1>> Özet
Türkiye Klinikleri Çocuk Psikiyatrisi Özel Dergisi; 2017;3(1):64-70
Çocuk ve Ergenlerde Psikotrop İlaçlarla İlişkili Endokrinolojik Yan Etkiler
DK Öğrenecek
Antalya
Psikotroplar birçok psikiyatrik hastalığın tedavisinde yaygın şekilde kullanılmaktadır. Bu ilaçlar çocuk ve ergenlerde gelişimsel dönemlerine uygun olmayan tiroid, kan şekeri, cinsiyet hormonları düzeyi, büyüme hızı ve kemik metabolizmasını içeren pek çok yan etkiye neden olabilmektedir. Çocuk ve ergenlerde ağırlık artışı ve diyabet ile en fazla ilişkili olan antipsikotik ilaç olanzapinken, aripiprazol ve ziprasidon en düşük riske sahiptir. Hiperglisemi açısından da en yüksek riskli ajanlar olanzapin ve klozapindir. Risperidon kullanımında hiperprolaktinemi açısından dikkatli olunmalıdır. Lityum, valproat ve karbamazapin tedavisi çeşitli düzeylerde tiroid fonksiyonlarını etkileyebilmektedir. Genç kızlarda valproat tedavisi hiperandrojenizm ve polikistik over sendromun neden olabilir. Selektif seratonin geri alım inhibitörleri ve venlafaksin tedavisi kilo artışı açısından minimal risk barındırmaktadır.
Endocrine Side Effects Related with Psychotropic Drugs in Children and Adolescence
Psychotropic drugs widely being prescribed for the treatment of several psychiatric disorders. These drugs can cause many side effects in children and adolescents, such as those related with thyroid, blood sugar, level of sex hormones, growth rate and bone metabolism. While the antipsychotic drug that is associated with weight increase and diabetes in children and adolescents most is olanzapine, aripiprazole and ziprasidone carry the lowest risk. The most risky agents in terms of hyperglycemia development are olanzapine and clozapine. Use of risperidone should be undertaken with caution since it may increase prolactin levels. Thyroid functions can be affected in different levels by lithium, valproate and carbamazepine treatments. Valproat treatment may lead to hyperandrogenism and polycystic ovary syndrome in young women. Selective serotonin reuptake inhibitors and venlafaxine treatments have minimal risk for weight gain.

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