Dergi Ara >>
Yıl:2001; Cilt: 12; Sayı: 3>> Özet
TAM METİN
Türk Psikiyatri Dergisi; 2001;12(3):211-224
Somatizasyonun ve ilişkili sendromlarının biyolojisi
A Sağduyu
Başkent Ü. Tıp Fak. Psikiyatri ABD
Somatizasyon terimi organik bir nedeni bulunamayan bedensel yakınmaları tanımlamak için kullanılmıştır. Somatoform bozukluklar içinde bulunan bir grup rahatsızlığın temel belirtisidir. Diğer yandan alttaki depresyon ya da anksiyete bozukluğu gibi bir ruhsal bozukluğun kliniğe yansıyan görünümü de olabilir. Yaygındır, kronik işlev bozukluğuna ve yüksek tedavi harcamalarına neden olur. Nevrasteni, kronik yorgunluk sendromu, myaljik ensefalomyelit ve fibromyalji gibi bir grup hastalıkta da benzer şekilde bedensel yakınmalar olup, açık bir şekilde organik etiyolojileri gösterilememiştir. Gelişen tıbbi teknolojinin de yardımıyla, son 20 yılda gerek somatoform bozuklukların, gerekse de ilişkili olabilecek diğer sendromların biyolojik etiyolojileri hakkında yeni bulgular elde edilmeye başlanmıştır. Bunlara örnek olarak serebral lateraliteyi, periferik uyarıların filtre edilmesindeki bozulmayı, hipokortizolizmi, viral enfeksiyonları ve otoimmüniteyi destekleyen bulgular sayılabilir. Bu gelişmeler somatizasyon tanımının gözden geçirilmesine ve tıptaki bedensel-ruhsal ayırımının yapaylığına işaret etmektedir, 20 yıl önce ruhsal kökenli olduğu söylenen pekçok olguda organik faktörlerin önemli olduğu açığa çıkmıştır. Yapılacak araştırmalar somatoform ve ilişkili bozukluklardaki biyolojik süreçleri daha iyi anlamamıza ve etkili tedavi yöntemleri bulmamıza katkıda bulunacaktır.
Biology of Somatization and Related Syndromes
Somatization is a term used for physical complaints without an organic pathology. Somatic symptoms are the main feature of somatoform disorders. They also may be a clinical presentation of mental disorders, especially depressive and anxiety disorders. Somatization is a common phenomenon and causes chronic disability and high treatment expenditure. There is a group of disorders like neurasthenia, chronic fatigue syndrome, myalgic encephalomyelitis and fibromyalgia with physical symptoms without a clear demonstrable organic pathology. With the help of developments in medical technology, new evidence for the biological etiology of somatoform and related syndromes has been investigated for the last 20 [year]s. Examples of these include cerebral laterality, deficiency of filtering peripheral stimulus, hypocortisolism, viral infections and autoimmune abnormalities. All these findings suggest that the description of the somatization must be revised; a lot of cases which were seen as a psychological disorders are now known disorders with demonstrable organic pathologies. It is hoped that future research on somatoform disorders will increase our understanding of the biological etiology involved in somatization, so more effective treatment modalities may be offered to these patients.

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