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Yıl:2016; Cilt: 6; Sayı: 1>> Özet
Psikiyatride Güncel; 2016;6(1):13-22
Psikiyatride Endokrinolojik Değerlendirmeler
S Özsoy
Erciyes Üniversitesi, Kayseri
Psikiyatrik ve endokrin bozukluklar arasında oldukça yakın bir ilişki vardır. Endokrin bozukluklar sıklıkla psikiyatrik belirtiler gösterirler. Örneğin hipotalamo-pituiter-adrenal eksen bozuklukları, depresyon, anksiyete, psikoz, bilişsel işlev bozuklukları ve deliryum gibi psikiyatrik tablolara yol açabilir. Tiroid fonksiyon bozuklukları da psikiyatrik belirtilerle ilişkili olabilir. Bununla birlikte, psikiyatrik hastalıkların kendisi veya tedavilerinde kullanılan ilaçlar, bazı endokrin problemlere neden olabilir. Psikotrop ilaçlar; diabetes insipidus, uygunsuz antidiüretik hormon salınımı sendromu, tiroid fonksiyon bozuklukları, hiperparatiroidizm, hiperprolaktinemi ve polikistik over sendromu gibi endokrin yan etkilere yol açabilir. Bu yan etkilerin klinik belirtileri, psikotrop ilaç kullanan hastalarda rutin olarak sorgulanmalıdır. Bazı laboratuvar testleri, psikiyatri pratiğinde endokrin bozuklukları araştırmak için yararlı olabilir. Lityum alan hastalar, tiroid fonksiyon bozuklukları ve diabetes insipidus gelişmesi açısından yakından izlenmelidir. Antipsikotik kullanımı, hiperprolaktinemi açısından takibi gerektirir. Valproat alan genç kadınlar polikistik over sendromu geliştirme riski altındadırlar. Psikiyatri hastalarındaki endokrin problemlerin tanınması, izlenmesi ve tedavisi, psikiyatristler ile ilgili bölümlerdeki meslektaşları arasında yakın işbirliğini gerektirir.
Endocrine Evaluations in Psychiatry
There is a close relationship between endocrine and psychiatric disorders. Endocrine disorders frequently show psychiatric manifestations. For instance, hypothalamo-pituitary-adrenal axis dysregulation may cause psychiatric manifestations such as depression, anxiety, psychosis, cognitive dysfunctions and delirium. Thyroid dysfunctions may also be associated with psychiatric symptoms. However, psychiatric illnesses themselves or the medications used for their treatments may cause some endocrine problems. Psychotropic drugs may be responsible for endocrine adverse effects, including diabetes insipidus, syndrome of inappropriate antidiuretic hormone secretion, thyroid dysfunction, hyperparathyroidism, hyperprolactinemia, and polycystic ovary syndrome. Clinical manifestations of these adverse effects should be inquired routinely among patients taking psychotropics. Some laboratory tests may be useful to explore these endocrine dysfunctions in clinical psychiatry practice. Patients receiving lithium should be closely monitored for the development thyroid dysfunctions and diabetes insipidus. Treatment with antipsychotics requires monitorization of hyperprolactinemia. Young women taking valproate are at risk of developing polycystic ovary syndrome. Diagnosis, monitoring, and treatment of endocrine problems in psychiatric patients require a close collaboration between psychiatrists and their colleagues at the related departments.

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