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Yıl:2002; Cilt: 13; Sayı: 3>> Özet
TAM METİN
Türk Psikiyatri Dergisi; 2002;13(3):173-178
Şizofrenide depresyonu olan ile olmayan hastaların belirti yönünden ayrımı
Ö Aydemir, AE Danacı, Ş Pırıldar
Celal Bayar Ü Tıp Fak, Psikiyatri ABD, Manisa

Amaç: Şizofreni beş boyutu içinde barındıran bir sendromdur ve içinde pozitif belirtiler, negatif belirtiler, dezorganizasyon, depresyon ve bilişsel belirtiler bulunmaktadır. Bu boyutlardan depresyon şizofreninin her boyutuyla birlikte ve her dönemde ortaya çıkabilen bir bileşenidir. Bu çalışmada şizofreniyle eştanılı depresyonun şizofreni ile örtüşen ve ayırt eden belirtilerinin incelenmesi amaçlanmıştır.

Yöntem: İki üniversite hastanesi psikiyatri polikliniğine başvuran, 30 şizofreni ve 30 şizofreni ile birlikte BTA (Başka Türlü Adlandırılamayan) depresif bozukluk tanısı konan toplam 60 hasta araştırmaya alınmıştır. Hastalar Pozitif Belirtileri Değerlendirme Ölçeği (PBDÖ), Negatif Belirtileri Değerlendirme Ölçeği (NBDÖ), Calgary Şizofrenide Depresyon Ölçeği (CŞDÖ) ve Ekstrapiramidal Belirtileri Değerlendirme Ölçeği (EBDÖ) ile değerlendirilmişlerdir.

Bulgular: Şizofreni ile depresyonun örtüşen belirtilerini saptamak için, CŞDÖ toplam puanı ile PBDÖ, NBDÖ ve EBDÖ’nden elde edilen belirtiler arasındaki bağıntı araştırılmıştır ve duygulanımda küntleşme, apati, dikkat ve sanrılar ile depresyon toplam puanı anlamlı düzeyde bağıntılı bulunmuştur. Wilk’s Lambda yöntemi ile diskriminant analiz sonucunda, depresyonu olan ile olmayan şizofren hastaları depresif duygudurum ve değersizlik duygusu belirtilerinin ayırt ettiği saptanmıştır.

Sonuç: Hem örtüşen özelliklerin hem de ayırt eden belirtilerin ortak özelliği emosyonel özelliklerin şizofreniyle eştanılı depresyonun varlığını etkiler nitelikte olmasıdır. Olumsuz duygulanım emosyonel bileşen içinde olumsuz yüklü duyguların tabloda egemen olmasıdır. Belirti örüntüsündeki emosyonel bileşende olumsuz duygulanımın bulunmasının şizofrenide depresyon için bir belirleyici olarak kabul edilebileceği düşünülmektedir.
Distinguishing Depressive from Nondepressive Patients in Schizophrenia in Terms of Symptomatology
Objective: Schizophrenia is a syndrome with five dimensions and it contains positive symptoms, negative symptoms, disorganization, depression, and cognitive symptoms. Depression which is one of these dimensions can be seen with every dimension and in every phase of schizophrenia. In this study our aim was to examine the overlapping features and the discriminating symptoms of depression comorbid with schizophrenia.

Method: The subjects consisted of 30 patients diagnosed as schizophrenic with a concurrent depression, disorder, and 30 patients diagnosed as schizophrenic without a concurrent depression, admitted to the outpatient department of two university hospitals. Patients were assessed using the following measures: Calgary Depression Scale for Schizophrenia (CDSS), Scales for Assessment of Positive and Negative Symptoms (SAPS and SANS respectively), and Extrapyramidal Symptom Rating Scale (ESRS).

Results: For determining the overlapping features of schizophrenia with depression, symptoms drawn from SAPS, SANS and ESRS were correlated with CDSS score, and affective flattening, apathy, attention, and delusions were significantly correlated with total score of CDSS. By Wilks’ Lambda method, the discriminating symptoms of the depressive and schizophrenic patients from the only schizophrenic patients were found to be depressive mood and feelings of worthlessness.

Conclusion: The shared nature of the overlapping features and discriminating symptoms is the emotional component affecting the presence of depression comorbid with schizophrenia. Negative affectivity is the dominance of negative-loaded feelings in the emotional component. In symptomatology, the presence of negative affectivity in the emotional component is suggested to be a specifier for depression in schizophrenia.

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