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Yıl:2016; Cilt: 53; Sayı: 3>> Özet
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Nöropsikiyatri Arşivi; 2016;53(3):276-279
Bipolar Bozukluğu Olan Hastalarda Aile Öyküsü
O Özdemir, S Coşkun, EA Mutlu, PG Özdemir, A Atlı, E Yılmaz, S Keskin
Yüzüncü Yıl Üniversitesi, Van
Amaç: Bu çalışmada bipolar bozukluğu (BB) olan hastalarda aile öyküsünün incelenerek hastalığın genetik geçişinin daha iyi anlaşılması amaçlanmıştır. Yöntem: Çalışmaya 63 BB 1 hastası olan aile alındı. Örneklemi toplam 156 hasta oluşturdu. Çalışmaya alınma ölçütü hastanın ailesinde BB 1 öyküsünün olmasıydı. Hasta olan diğer aile bireylerinin tanıları dosyaları, hastane kayıtları incelenerek ve muayene edilerek doğrulandı. Bulgular: Tüm hastaların (156 hasta) 65’i kadın (%41,6), 91’i (%58,3) erkekti (erkek/kadın oranı: 1,40). Bozukluğun anne tarafından veya baba tarafından geçişi açısından değerlendirildiğinde benzer sonuçlar ortaya çıkıyordu. Toplamda anne tarafından 25, baba tarafından da 25 hasta vardı. Sonuç: Çalışmamızın bulguları akrabalık derecesi ile BB’un kalıtımı arasında önemli bir ilişki bulunduğunu, anne ve baba tarafından hastalığın geçişinin benzer olduğunu desteklemiştir.
Family History in Patients with Bipolar Disorder
Introduction: In this study, we aimed to better understand the genetic transmission of bipolar disorder by examining the family history of patients. Methods: Sixty-three patients with bipolar disorder and their families were included. The final sample comprised 156 bipolar patients and their family members. An inclusion criterion was the presence of bipolar disorder history in the family. The diagnosis of other family members was confirmed by analyzing their files, hospital records, and by calling them to the hospital. Results: Sixty-five patients were women (41.6%) and 91 were men (58.3%) (ratio of men/women: 1.40). When analyzing the results in terms of the transition of disease from the mother’s or father’s side, similar results were obtained: 25 patients were from the mother’s side and 25 patients were from the father’s side in 63 cases. Conclusion: The results of our study support the fact that a significant relationship exists between the degree of kinship and the heritability of bipolar disorder and, furthermore, that the effect of the maternal and paternal sides is similar on the transmission of genetic susceptibility

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