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Yıl:2016; Cilt: 53; Sayı: 3>> Özet
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Nöropsikiyatri Arşivi; 2016;53(3):257-262
Bipolar ve Unipolar Hastalarda Erişkin Dikkat Eksikliği ve Hiperaktivite Bozukluğu Eş Tanısı
H Harmancı, FÇ Çelikel, İ Etikan
Mehmet Akif Eğitim ve Araştırma Hastanesi, Şanlıurfa
Amaç: Bu çalışmada amacımız öncelikli olarak afektif bozukluk tanılı hastalarda dikkat eksikliği ve hiperaktivite bozukluğunun (DEHB) ne sıklıkta eşlik ettiğini belirlemektir. Aynı zamanda DEHB birlikteliğinin bipolar ve unipolar hastaların klinik özellikleri ile ilişkili olup olmadığını incelemek ve DEHB eş tanısı olan ve olmayan hastalarda olası baskın bir mizaç özelliğini araştırmaktır. Yöntem: Çalışmaya Ruhsal Bozuklukların Tanısal ve Sayımsal El Kitabı Yeniden Gözden Geçirilmiş Dördüncü Baskı (DSM-IV-TR) tanı ölçütlerine göre remisyonda olan 100 bipolar bozukluk tanılı hasta, 100 major depresif bozukluk tanılı hasta ve herhangi bir ruhsal hastalığı olmayan 100 sağlıklı gönüllü alınmıştır. Tüm katılımcılara Sosyodemografik ve Tıbbi Bilgi Formu verilmiş, DSM-IV Eksen I Bozuklukları için Yapılandırılmış Klinik Görüşme (SCID-1), Erişkin Dikkat Eksikliği ve Hiperaktivite Kendi Bildirim Ölçeği (ASRS), Wender Utah Derecelendirme Ölçeği (WUDÖ), Memphis, Pisa, Paris ve San Diego Mizaç Değerlendirme Anketi Türkçe Formu/ MPPS-MD (TEMPS-A) anketi uygulanmıştır. Bulgular: DEHB eş tanısı bipolar bozukluk tanılı grupta %48, major depresif bozukluk tanılı grupta %25 ve sağlıklı gönüllülerde %12 olarak bulunmuştur. DEHB eş tanılı bipolar hastalarda intihar girişimi öyküsü daha sıktır. DEHB eş tanısı olan bütün çalışma gruplarında depresif, siklotimik, sinirli ve endişeli mizaç puanları daha yüksek bulunmuştur. Sonuç: Çalışma sonuçlarına göre bipolar hasta grubunda DEHB eş tanısı anlamlı düzeyde daha yüksektir. DEHB eş tanılı bipolar hastalarda intihar girişimi öyküsü daha sıktır. Hem her iki hasta grubunda, hem de sağlıklı kontrollerde depresif, siklotimik, sinirli ve endişeli mizaç puanları anlamlı düzeyde yüksek bulunmuştur.
Comorbidity of Adult Attention Deficit and Hyperactivity Disorder in Bipolar and Unipolar Patients
Introduction: The co-occurrence of attention deficit hyperactivity disorder (ADHD) in affective disorder patients is considerably high. The aims of the present study were to search for the frequency and impact of ADHD co-occurrence on the clinical features of affective disorders and to examine the relationship between the dominant affective temperaments and ADHD. Methods: In total, 100 patients with bipolar disorder (BD), 100 patients with major depressive disorder (MDD), and 100 healthy controls (HC) were included. All diagnoses were assigned according to DSM-IV-TR criteria. The Adult Attention Deficit and Hyperactivity Self-Report Scale (ASRS); Wender Utah Rating Scale (WURS); and Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire (TEMPS-A) were applied to all participants. Results: The percentage of BD patients meeting the criteria for a diagnosis of current ADHD was 48% compared with the percentage of MDD patients and HCC subjects, i.e., 25% and 12%, respectively. ADHD was significantly more frequent in bipolar adults than in not only HC but also depressive patients. In the BD group, patients with a comorbid ADHD diagnosis had significantly more suicidal history than those without ADHD. The scores of the temperament traits, namely depressive, cyclothymic, irritable, and anxious, were significantly higher in subjects with ADHD in all groups, including in HC. Conclusion: The most important findings of the present study were the observations that (1) the frequency of ADHD is considerably high among bipolar patients; (2) the frequency of suicide attempts is high in the bipolar patient group with comorbid ADHD; and (3) depressive, cyclothymic, irritable, and anxious temperaments are significantly associated with ADHD comorbidity in bipolar and depressive patients as well as in HC. The high comorbidity and chronic course of ADHD and its possible negative influence on the course of both disorders increase the importance of screening for adult ADHD.

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