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Yıl:2016; Cilt: 9; Sayı: 2>> Özet
Türkiye Klinikleri Psikiyatri Özel Dergisi; 2016;9(2):85-88
Uyku ve Uyanıklığın Düzenlenmesinde Nöropeptitler
S Yetkin
GATA, Ankara
Nöropeptitler nöronal iletişimin modülasyonunu sağlayan nöronal sinyal oluşturan moleküllerdir. Enerji homeostazisi, beslenme, otonomik regülasyon, emosyonel işlem, ödül ve uykuuyanıklık gibi geniş bir grup beyin işlevini etkilerler. Uyku ve uyanıklığın modülasyonunda nöropeptitlerin önemi son yıllarda anlaşılmıştır. Uyku-uyanıklık döngüsü bazı fizyolojik sistemlerin de katıldığı, birkaç beyin bölgesinin koordinasyonunu gerektirir. Nöropeptitler uygun uykuuyanıklık davranışının gerçekleşebilmesi için bu fizyolojik sistemlerin entegrasyonunu sağlar. Bu makalede uyku ve uyanıklığın regülasyonunda önemli bazı nöropeptitlerin etkilerini sunmak amaçlanmıştır.
Neuropeptides in the Regulation of Sleep and Wakefulness
Neuropeptides are neuronal signaling molecules that modulate neuronal communication. They influence a wide range of brain functions, including energy homeostasis, feeding, autonomic regulation, emotional processing, reward, and sleep-wake regulation. The importance of neuropeptides in the modulation of sleep and wakefulness has become apparent in the recent years. Sleep-wake cycle require the coordination of several brain regions and engage some physiological systems. Neuropeptides integrate physiological subsystems to generate appropriate sleep-wake behaviors. This article is intended to present the impact some important neuropeptides on the sleepwake regulation.

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