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Yıl:2016; Cilt: 53; Sayı: 2>> Özet
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Nöropsikiyatri Arşivi; 2016;53(2):178-180
Olanzapin Kullanımına Bağlı Çekilme Diskinezisi ve Süpersensitivite Psikozu
H Karaş, M Güdük, Ö Saatcioğlu
Şişli Kolan International Hastanesi, İstanbul
Tardiv diskinezi sıklıkla yıllar boyu antipsikotik ilaç kullanımından sonra ortaya çıkmaktadır ve yaşam boyu tedavi dozu ile ilişkili görünmektedir. Tardiv diskinezinin bir alt tipi olarak kabul edilen çekilme diskinezisi tablosunda diskinezi belirtileri ilaç dozunun hızlı azaltılması veya ani kesilmesinden kısa bir süre sonra ortaya çıkar. Sıklıkla tardiv diskineziyle birlikte görülen ve oluşumunda tardiv diskineziyle benzer mekanizmaların rol oynadığı öne sürülen bir durum olan süpersensitivite psikozu, kullanılan antipsikotiğin hızlı azaltılması veya ani kesilmesine bağlı olarak oluşan psikotik relaps durumudur. Genel olarak atipik antipsikotikler tipik olanlarla kıyaslandığında tardiv diskineziye daha az yatkınlık oluşturma ile ilişkilendirilir. Bunun da ötesinde klozapinin ve olanzapinin tardiv diskinezi bulgularında düzelme veya tamamen iyileşme sağlama potansiyeli olduğu bildirilmiştir. Bu yazıda olanzapin tedavisinin kesilmesine bağlı olarak çekilme diskinezisi ve supersensitivite psikozu olgusu tartışılmıştır.
Withdrawal-Emergent Dyskinesia and Supersensitivity Psychosis Due to Olanzapine Use
Tardive dyskinesia (TD) usually appears after years of antipsychotic drug use and appears to be related to the total lifetime medication dose. In withdrawal-emergent dyskinesia (WE-D), which is considered to be a subtype of TD, dyskinetic symptoms often appear shortly after a rapid reduction in antipsychotic drug dose or sudden discontinuation of the drug. Supersensitivity psychosis, which is frequently observed along with TD and is considered to have a similar etiology as TD, is a psychotic relapse phenomenon that occurs after the withdrawal of an antipsychotic drug or a rapid reduction in the drug dosage. In general, atypical antipsychotics tend to be associated with less propensity to cause TD when compared with typical antipsychotics. Furthermore, olanzapine and clozapine may have a therapeutic potential in improving or totally curing TD. In this study, a case of WE-D because of discontinuing olanzapine use and supersensitivity psychosis is discussed.

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