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Yıl:2016; Cilt: 53; Sayı: 1>> Özet
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Nöropsikiyatri Arşivi; 2016;53(1):42-45
Büyük Oksipital Sinir Blokajının Migren Profilaksisindeki Etkinliği
N İnan, LE İnan, Ö Coşkun, T Tunç, M İlhan
Gazi Üniversitesi, Ankara
Amaç: Periferik sinir blokları uzun süredir primer başağrılarının tedavisinde kullanılmaktadır. Bu çalışmada büyük oksipital sinir (GON) blokajının migren profilaksisinde etkinliğinin gösterilmesi amaçlanmıştır. Yöntem: Büyük oksipital sinir blokajı uygulanan aurasız migren tanılı hastaların verileri toplanarak iki gruba ayrıldı. Grup PGON (n=25); medikal migren profilaksisi almakta iken GON blokajı uygulanan hastalar ve Grup GON (n=53) sadece GON blokajı uygulanan hastalar. Migren tanıları IHS sınıflamasına göre konulmuştur. Toplam 78 hasta verileri analiz edilmiştir. Üç aylık takip perioduna ait verilerde başağrısı atak frekansı, başağrısı süresi ve şiddet değerleri grup içi ve gruplar arası karşılaştırılmıştır. Bulgular: Büyük oksipital sinir blokajı sonrası her iki grup başağrısı takip parametrelerinde benzer azalmalar göstermiştir. Grup GON de başağrısı atak frekansı 15,73±7,21’den 3. ayda 4,52±3,61’e Grup PGON’de 13,76±8,07’den 3,28±2,15’e inmiştir (p<0,05). Baş ağrısı süresi Grup GON’de 18,51±9,43’ten 3. ayda 8,02±5,58’e Group PGON’de 15,20±9,16’dan 7,20±4,16’ya inmiştir (p<0,05). Baş ağrısı şiddeti Grup GON’de 8,26±1,32’den 3. ay da 5,16±2,64’e Grup PGON’de 8,08±0,90’dan 5,96±1,20’e inmiştir (p<0,05). Gruplar arası karşılaştırmada istatistiksel olarak anlamlı fark tespit edilmemiştir (p>0,05). Sonuç: Bu çalışma başağrısı parametrelerinde her iki grupta anlamlı azalma olduğunu göstermiştir. Grup PGON de medikal profilaksiye yeterli yanıt vermeyenlerde GON blokajı yapıldığı için Grup PGON deki başağrısı parametrelerinde azalma Grup GON’da olduğu gibi GON blokajlarına bağlanmıştır. Sonuç olarak, lokal anestetiklerle yapılan tekrarlayıcı GON blokajları migren profilaksisinde özellikle medikal tedaviye yeterli yanıt vermeyen ya da kullanamayanlarda tek başına da etkili alternatif olabileceği çalışmamızda gösterilmiştir.
Effectiveness of Greater Occipital Nerve Blocks in Migraine Prophylaxis
Introduction: Peripheral nerve blocks have been used in primary headache treatment since a long time. In this study, we aimed to examine the efficiency of greater occipital nerve (GON) block in migraine prophylaxis. Methods: Data from migraine without aura patients who had GON block were collected and divided into two groups: Group PGON (n=25), which included patients who were under medical prophylaxis and had GON block, and Group GON (n=53), which included patients who had only GON blocks. Migraine was diagnosed using International Headache Society (IHS) classification. Data of 78 patients were analyzed. Headache attack frequency, headache duration, and severity were compared between and within groups in a 3-month follow-up period. Results: The decrease in headache parameters after GON block in both groups was significantly similar. Headache attack frequency decreased from 15.73±7.21 (pretreatment) to 4.52±3.61 (3rd month) in Group GON and from 13.76±8.07 to 3.28±2.15 in Group PGON (p<0.05). Headache duration decreased from 18.51±9.43 to 8.02±5.58 at 3rd month in Group GON and from 15.20±9.16 to 7.20±4.16 in Group PGON (p<0.05). Headache severity decreased from 8.26±1.32 to 5.16±2.64 in Group GON and from 8.08±0.90 to 5.96±1.20 in Group PGON (p<0.05). There was no statistically significant difference between the groups in 3rd month after treatment (p>0.05). Conclusion: This study showed significant decreases in headache parameters in both groups. As GON blocks were performed in patients unresponsive to medical prophylaxis, a decrease in the headache parameters in Group PGON similar to that in Group GON can be attributed to GON blocks. Consequently, these results show that repeated GON blocks with local anesthetic can be an effective alternative treatment in migraine patients who are unresponsive to medical prophylaxis or who do not prefer to use medical prophylaxis.

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