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Yıl:2016; Cilt: 27; Sayı: 1>> Özet
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Türk Psikiyatri Dergisi; 2016;27(1):41-46
Eğitimsizler İçin Modifiye Edilen Mini Mental Testin (MMSE-E) Türk Toplumunda Alzheimer Hastalığı Tanısında Geçerlik ve Güvenilirlik Çalışması
GB Yıldız, EU Özçelik, M Kolukısa, AT Işık, E Gürsoy, G Kocaman, A Çelebi
Bezmialem Vakıf Üniversitesi, İstanbul
Amaç: Eğitimsizler için modifiye edilmiş olan Mini Mental Test’in (MMSE-E) Türk Alzheimer popülasyonunda geçerlilik ve güvenilirliliğini araştırmak. Gereç ve Yöntem: Çalışmaya okuma-yazma bilmeyen 107 Alzheimer hastası (kadın:65, erkek:42) ile 68 (kadın:36, erkek:32) okuma-yazma bilmeyen sağlıklı gönüllü alındı. Tüm deneklere MMSE-E, ve Geriatrik Depresyon Skalası (GDS), hasta grubuna ise ek olarak Temel Günlük Yaşam Aktiviteleri ölçeği (T-GYA) uygulandı. Hastalık Klinik Demans Derecelendirme Ölçeği’ne (CDR) göre evrelendirildi. MMSE-E’nin en uygun kesme noktasını belirlemek için ROC (Receiver Operating Characteristic) analizleri yürütüldü ve en uygun kesme değeri (cut-off score) için pozitif/negatif yordayıcı değerleri hesaplandı. MMSE-E’nin iç tutarlılığı Cronbach katsayısı kullanılarak ölçüldü. Ayrıca MMSE-E toplam puanıyla CDR, T-GYA ve GDS ile korelasyonuna bakıldı. Bulgular: MMSE-E’nin CDR (-0.82, p=0.000) ve T-GYA (-0.051, p=0.000) ile yüksek bir korelasyonu olduğu tespit edilmiştir. En yüksek duyarlık (99.0/100.0), özgüllük (98.5/97.0) ve eğri altında kalan alan-AUC (1.0/1.0) sonuçlarına karşılık gelen MMSE-E toplam puan için kesme noktası 23/24 puan olarak belirlenmiştir. MMSE-E toplam puanı yüksek bir iç tutarlılık (= 0.70) göstermiştir. Sonuç: MMSE-E toplam puanının Alzheimer hastalarını normal sağlıklı bireylerden ayırabildiği gözlenmiştir.
Validity and Reliability Studies of Modified Mini Mental State Examination (MMSE-E) For Turkish Illiterate Patients With Diagnosis of Alzheimer Disease
Objective: To investigate the validity and reliability of modified Mini Mental State Examination (MMSE-E) for illiterate patients in a Turkish population with Alzheimer’s disease (AD). Method: A total of 107 illiterate patients with Alzheimer’s Disease (women: 65, men: 42) and 68 illiterate healthy volunteer subjects (women: 36, men: 32) were included in the study. MMSE-I and Geriatrics Depression Scale were performed on all subjects, Alzheimer patients were also administered Basic Activities of Daily Living (B- ADL). Clinical Dementia Rating (CDR) was used to determine the severity of disease, while a receiver operating characteristic (ROC) analysis was performed to analyze the cut-off scores of MMSE-I, and the positive/negative predictive values that were calculated for the optimal cut-off scores. Internal consistency was measured using Cronbach’s coef?cient ?. Additionally, correlations between total MMSE-I score and the CDR, B-ADL, and GDS scores were examined. Results: The MMSE-I scores signi?cantly and inversely correlated with CDR (-0.82, p=0.000) and B-ADL scores (-0.051, p=0.000). The optimal cut-off points of MMSE-I were 23/24, which yielded a sensitivity of 99.0% - %100.0, a specificity of 98.5% - 97.0%, and an AUC of 1.0/1.0, respectively. Reliability of the MMSE-I was high ???= 0.70). Conclusion : The total MMSE-I score was able to differentiate the AD group from the control group.

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