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Yıl:2015; Cilt: 53; Sayı: 3>> Özet
TAM METİN
Yeni Symposium; 2015;53(3):51-56
Siklotimisi Olan Bireylerde Atipik Major Depresif Epizod ve Sosyal Fobi Birlikteliğinin Varlığı Manik ya da Hipomanik Kaymanın Öncüsü Olabilir mi?
TD Berkol, A Kuoyuncu, E Kırlı, E Alataş, A İslam
Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, Ankara
Major depresif epizodların (MDE) önemli bir kısmının bipolar spektruma ait olabileceği belirtilmektedir. Fakat “soft” bipolar belirtiler klinik uygulamada yeterince araştırılmadığı için gözden kaçmaktadır. MDE’lerin yaklaşık üçte biri siklotimiye ek olarak saptanan epizodlar olarak (BP-II ½ ) bildirilmiştir. Antidepresan tedaviler ile bu hastalarda manik/ hipomanik kayma daha sık olabilmektedir. Bu yazıda, antidepresan tedavi ile hipomanik kayma görülen siklotimiye eklenmiş major depresif epizodlu beş hasta sunulmaktadır. Ayrıca bu hastalarda görülen depresyonun atipik ve mevsimsel özelliği ile sosyal fobi eş tanısı gibi değişkenlerin bu hasta grubunda kaymanın öngörücüsü olabileceği hipotezi tartışılacaktır.
May comorbidity of atypical major depressive episode and social phobia be a predictor for a possible switch to mania or hypomania in individuals diagnosed with cyclothymic disorder?
It has been suggested that an important part of major depressive episodes (MDE) could be in the bipolar spectrum. However, because “soft” bipolar symptoms are clinically not adequately questioned, these features are overlooked in practice. It has been reported that approximately one-third of MDEs have cyclothymia in addition to major depressive episodes (BP-II ½). Manic/hypomanic switches occur more often in these patients under antidepressant treatments. In this report, we present five cases of depressive episode patients with cyclothymic disorder who had hypomanic switch under antidepressant treatment. We will also discuss whether factors like atypical phenomena and seasonal pattern of depression, and comorbid social phobia in this patient group could be a predictor of switch.

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