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Yıl:2015; Cilt: 26; Sayı: 4>> Özet
TAM METİN
Türk Psikiyatri Dergisi; 2015;26(4):229-235
Şizofreni Tanılı Hastalarda Eksiklik Sendromu ile Klinik Belirtiler, Yaz Doğumları ve Ailesellik Arasındaki İlişki
L Mete, Ö Sarıkaya, A Erol
İzmir Atatürk Eğitim ve Araştırma Hastanesi, İzmir
Amaç: Bu çalışmada, eksiklik sendromu olan ve eksiklik sendromu olmayan şizofreni tanılı hastaların, negatif ve pozitif belirtilerin şiddeti, yaz doğumu ve akrabalarında psikoz görülme sıklığı yönünden karşılaş- tırılması amaçlanmıştır. Yöntem: Çalışmaya DSM-IV için yapılandırılmış klinik görüşme (SCID-I) ile şizofreni tanısı konan, 18-65 yaş grubundan 110 hasta alınmış, tüm hastalara Negatif Belirtileri Değerlendirme Ölçeği (NBDÖ), Pozitif Belirtileri Değerlendirme Ölçeği (PBDÖ), Eksiklik Sendromu Çizelgesi (ESÇ) uygulanmış ve sosyodemografik bilgiler alınmıştır. Bulgular: Eksiklik sendromu olan grupta, negatif ve pozitif belirtilerin şiddetiyle birlikte, yaz doğumluların oranı eksiklik sendromu olmayan gruba göre anlamlı derecede daha yüksek bulundu. Ailede psikoz öykü- sü, eksiklik sendromu olan grupta eksiklik sendromu olmayan gruba göre yüksek olmakla birlikte, aradaki fark istatistik anlamlılık düzeyinde değildi. Sonuç: Eksiklik sendromu olan grupta klinik belirtilerin daha şiddetli ve yaz doğumluların daha fazla olduğu yönündeki bulgularımız, bu iki grubun farklı patofizyolojileri olan iki ayrı şizofreni türü olduğuna dair ek kanıt sağlamaktadır. Ancak, ailede psikoz öyküsünün iki grup arasında istatistik anlamlılık düzeyinde farklılık göstermemesi, eksiklik sendromu olan grubun çevresel etmenlerden çok genetik etmenlerle ilişkili olduğu iddiasının daha fazla araştırılmaya ihtiyacı olduğunu dü- şündürmektedir.
The Relationship of Deficit Syndrome with Clinical Symptoms,Summer Births and Heritability in Patients with Schizophrenia
Aim: The aim of this study was to compare deficit schizophrenia patients with non-deficit schizophrenia patients for negative and positive symptome scores, rate of summer births, and rate of familial history of psychosis. Method: 110 patients with schizophrenia diagnosed via Structured Clinical Interview for DSM-IV (SCID-I) aged between 18-65 were included in the study. All the patients were evaluated using the Scale for the Assessment of Negative Symptoms (SANS), Scale for the Assessment of Positive Symptoms (SAPS), and The Schedule for the Deficit Syndrome (SDS), and sociodemographic information was obtained. Results: The deficit syndrome group had higher negative and positive scores compared to the non-deficit group. The rate of summer births were higher in the deficit group. Although the rate of positive family history for psychosis was higher in deficit group compared with the non-deficit group, the difference did not achieve statistical significance. Conclusion: Our results that depict higher severity of negative and positive symptom scores and higher rate of summer births with deficit schizophrenia, provides more evidence that deficit and non-deficit schizophrenia are different subtypes having different pathophysiologies. But statistically nonsignificant difference of positive familial history between two groups suggests that the thesis of deficit schizophrenia may be related to genetic factors more than enviromental factors needs to be invesigated further.

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