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Yıl:2015; Cilt: 52; Sayı: 3>> Özet
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Nöropsikiyatri Arşivi; 2015;52(3):303-308
Madde Kullanım Bozukluğu Olan ve Olmayan Erkek Şizofreni Hastalarında Premorbid Kişilik Bozuklukları: Kişilik Bozukluğu Eştanıya Aracılık Ediyor mu?
N Altunsoy, ŞY Şahiner, MC Külük, T Okay, SU Kaymak, Ç Aydemir, E Göka
Ankara Numune Eğitim ve Araştırma Hastanesi, Ankara
Amaç: Şizofreni hastalarında madde kötüye kullanımı önemli bir klinik sorun olmasına rağmen, bu hastaların neden alkol ve madde kullandıklarını açıklayan az sayıda kanıt bulunmaktadır. Bu çalışmada, premorbid kişilik bozukluklarının madde kötüye kullanımı üzerine etkisi olup olmadığının araştırılması planlanmıştır. Yöntem: Bu çalışmaya Ankara Numune Eğitim ve Araştırma Hastanesi Psikiyatri Polikliniği’ne başvuran, madde kullanım bozukluğu komorbiditesi olan 40 erkek şizofreni hastası ve komorbiditesi olmayan 40 erkek şizofreni hastası dahil edilmiştir. Premorbid kişilik bozukluğu araştırırken, her hasta ve hasta yakınıyla yapılandırılmış klinik görüşme formu kullanılarak görüşme yapılmıştır. Bulgular: Komorbidite grubunda 32 hasta (%80) ve komorbiditesiz grupta 28 hasta (%70) olmak üzere; çalışmaya katılan şizofreni hastalarının büyük bölümünde en az bir premorbid kişilik bozukluğu saptanmıştır. Antisosyal (%35’e karşı %0; p<0,001) ve borderline (%37,5’e karşı %5; p=0,001) kişilik bozuklukları komorbidite grubunda daha sık saptanmıştır. Kaçıngan (%10’a karşı %35; p=0,014) ve obsesif kompulsif (%0’a karşı %15; p=0,026) kişilik bozuklukları ise komorbiditesiz grupta daha sık saptanmıştır. Komorbidite grubundaki hastaların premorbid kişilik bozukluğu tiplerine göre karşılaştırmasında, premorbid antisosyal kişilik bozukluğu olan şizofreni hastalarında işsizlik ve hastane yatışı daha fazla, şizofreni başlangıç yaşı daha küçük bulunmuştur (p=0,034, p=0,038, p=0,035). Bununla birlikte premorbid borderline kişilik bozukluğu olan şizofreni hastalarında madde kullanmaya başlama yaşı daha küçük bulunmuştur (19±5; p=0,028). Sonuç: Bu çalışma, madde kullanım bozukluğu olan şizofreni hastalarının bir çok bakımdan farklı özelliklere sahip olduğunu ve bu farklılıkların bir kısmının da premorbid kişilik bozukluklarıyla ilşkili olabileceğini göstermektedir.
Premorbid Personality Disorders in Male Schizophrenic Patients with or without Comorbid Substance Use Disorder: Is Dual Diagnosis Mediated by Personality Disorder?
Introduction: Although substance abuse is an important clinical problem in schizophrenic patients, very little evidence explains why these patients use drugs and alcohol. This study therefore aimed to examine whether premorbid personality disorders affect substance abuse. Methods: The sample included 40 male schizophrenic patients with and 40 male schizophrenic patients without substance use disorder comorbidity who had applied to Ankara Numune Research and Training Hospital. Each participant and a family member were interviewed in a structured clinical interview that addressed premorbid personality disorders. Results: Altogether, 32 patients (80%) in the group with comorbidity and 28 (70%) in the group without comorbidity had a premorbid personality disorder. Antisocial (35% vs. 0%; p<0.001) and borderline (37.5% vs. 5%; p=0.001) personality disorders were more often detected in the group with comorbidity, while avoidant (10% vs. 35%; p=0.014) and obsessive–compulsive (0% vs. 15%; p=0.026) personality disorders were less frequently found in this group. Comparing the group with comorbidity with premorbid personality types, schizophrenic patients with premorbid antisocial personality disorder were more frequently unemployed and hospitalized as well as had an earlier onset age of schizophrenia (p=0.034, p=0.038 and p=0.035, respectively). Schizophrenic patients with premorbid borderline personality disorder had a significantly earlier onset age of substance use (19±5; p=0.028). Conclusion: Schizophrenic patients with substance use comorbidity variously differ from those without comorbidity and some of these differences may be associated with premorbid personality disorders.

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