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Yıl:2002; Cilt: 10; Sayı: 4>> Özet
Psikiyatri Psikoloji Psikofarmakoloji (3P) Dergisi; 2002;10(4):351-356
Alzheimer hastalığında davranışsal belirtiler: Vasküler demans ile karşılaştırmalı bir çalışma
A Cansever, E Dönmez, Ö Uzun, A Özşahin
GATA Psikiyatri ABD, Ankara
Amaç: Bu çalışmada Alzheimer hastalığında (AH) davranışsal belirtilerin yaygınlığının araştırılması ve vasküler demans (VD) olguları ile karşılaştırılması amaçlanmıştır. Yöntem: Çalışmaya 55 AH ve 40 VD tanılı olgu alındı. AH ile VD ayırımı DSM-IV tanı ölçütleri, Hachinski İskemik Skorlama Ölçeği ve bilgisayarlı beyin tomografisi sonuçlarına göre yapıldı. Klinik evreleme Global Detoriasyon Ölçeği ile belirlendi. Davranışsal belirtiler Alzheimer Hastalığında Davranış Patolojileri Ölçeği (BEHAVE-AD) ile tarandı. Bulgular: AH olgularının %87.3’ünde, VD olgularının ise tamamında en az bir davranışsal belirti olduğu bulundu. En yaygın davranışsal belirtiler AH’nda duygudurum belirtileri (%69.1), anksiyete ve fobiler (%65.5) ve uyku bozuklukları (%65.5); VD’ta ise uyku bozuklukları (%87.5), duygudurum (%85) ve saldırganlık belirtileri (%82.5) olarak saptandı. VD olgularında saldırganlık ve uyku bozukluğu belirtilerinin yaygınlığı, AH olgularından anlamlı oranda daha yüksek bulundu. İki grup arasında diğer davranışsal belirtilerin görülme oranları yönünden anlamlı farklılık görülmedi. Tartışma: AH ve VD olgularında davranışsal belirtiler yaygın olarak görülmektedir. Klinik değerlendirilmelerde, bilişsel belirtilerin yanında davranışsal belirtiler de göz önünde bulundurulmalıdır.

Behavioural symptoms in Alzheimer’s disease: A comparison study with vascular dementia
Objective: We aimed to examine to prevalence of behavioural symptoms in Alzheimer’s Disease (AD), and to compare with symptoms of vascular dementia (VD). Method: The study included 55 AD and 40 VD patients. Differential diagnosis between AD and VD was carried out by means of the DSM-IV criteria, computerized tomography, and Hachinski Ischemic Score. The clinical stage of dementia was assessed using the Global Deterioration Scale. Behavioural symptoms were screened using the BEHAVE-AD. Results: At least one behavioural symptom was found in 87.3% of AD, and all of the VD patients. The most common types of behavioural symptoms were affective disturbances (69.1%), anxieties and phobias (65.5%), and sleep disturbances (65.5%) in AD patients, and sleep disturbances (87.5%), affective disturbances (85%), and aggressivity (82.5%) in VD patients, respectively. The prevalence of aggressivity, and sleep disturbance symptoms was significantly higher among VD patients than AD patients. There was not statistically significant difference in other variables between groups. Conclusion: Our results showed that behavioural symptoms are not rare in dementia and additionally to cognitive symptoms, behavioralsymptoms must also be taken in to consideration during clinical evaluation.

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