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Yıl:2014; Cilt: 24; Sayı: 1>> Özet
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Klinik Psikofarmakoloji Bülteni; 2014;24(1):23-30
Elektrokonvülsif terapide anestezik ajanların ve tanıların nöbet süreleri, derlenme süreleri ve komplikasyonlar üzerine olan etkilerinin değerlendirilmesi
A Tüfek, M Bulut, O Tokgöz, F Çelik, ZB Yıldırım, A Atlı, MC Kaya, H Karaman.
Dicle University, Diyarbakır
Amaç: Bu çalışmada elektrokonvulzif terapi (EKT) anestezisinde kullanılan üç farklı anestezik ajanın ve tanıların nöbet süreleri, hemodinamik parametreler, derlenme süreleri ve yan etkiler üzerine olan etkilerinin retrospektif olarak değerlendirilmesi amaçlandı. Metod: 1 Eylül 2009-30 Haziran 2012 tarihleri arasında Dicle Üniversitesi Psikiyatri Kliniğinde EKT endikasyonu konulan ve genel anestezi altında EKT uygulanan toplam 179 hastanın 1342 EKT seansı retrospektif olarak incelendi. EKT endikasyonları ve kullanılan anestezik ajanların, uygulanan EKT sayısı, motor ve EEG nöbet süreleri, anesteziden derlenme süreleri, hemodinamik değişiklikler ve komplikasyonlar ile ilişkisi analiz edildi. Bulgular: Çalışmaya dahil edilen 179 hastanın yaş ortalaması 36.7±7.3 yıl idi. %50.8’i (n=91) erkek, %49.2’si (n=88) kadındı. En çok kullanılan anestezik ajan propofol idi (%73.2). Hastaların %50.8 major depresyon, %28.5’i bipolar bozukluk, %12.8’i şizofreni tanısıyla takip edilmekteydi. Uygulanan toplam 1342 EKT seansının 179’u (%13.3) başarısız olarak kabul edildi. Başarısız EKT’lerin %92.2’sinde propofol anestezisi kullanılmıştı. Elektrokonvulzif terapi endikasyonu koyduran tanıların motor ve EEG nöbet süreleri, spontan solunum başlangıcı, göz açma, sözel uyaranlara yanıt verme süreleri, hemodinamik parametrelerdeki değişiklikler ve komplikasyonlar arasında istatistiksel olarak anlamlı ilişki saptanmadı. Propofol grubunda nöbet ve derlenme süreleri ketamin ve etomidat gruplarına göre anlamlı olarak daha kısaydı (p<0.05). Etomidat grubunda ise EEG nöbet süreleri propofol ve ketamin grubuna göre daha uzundu (sırasıyla p<0.001, p<0.05). Sonuç: Sonuç olarak motor ve EEG nöbet süreleri, spontan solunum başlangıcı, göz açma, sözel uyaranlara yanıt verme süreleri, hemodinamik parametrelerdeki değişiklikler ve komplikasyonlar üzerine tanıların bir etkisi bulunmamaktadır. Ancak kullanılan anestezik ajanlar tüm bu parametreleri etkilemektedirler.
The Evaluation of the Effects of Anesthetic Agents and Diagnosis on the Seizure Durations, Recovery Times and Complications in Electroconvulsive Therapy
Objective: In this study was aimed to evaluate of the effects of three different anesthetic agents and diagnosis on the seizure durations, recovery times, hemodynamic parameters and side effects in ECT, as retrospectively. Methods: We have retrospectively examined 1342 ECT sessions of 179 patients that was performed under general anesthesia at Psychiatry Department of Dicle University between 1 September 2009 and 30 June 2012. The relation between diagnosis of the patients, anesthetic agents and the number of ECT, motor and EEG seizure durations, recovery times from anesthesia, hemodynamic changes, and complications were analyzed. Results: The mean age of the 179 patients that enrolled to the study were 36.7±7.3 years. 50.8% (n=91) of the patients were male and 49.2% (n=88) of were female. The most commonly used anesthetic agent was propofol (73.2%). 50.8% of the patients were diagnosed as major depression, 28.5% of were bipolar disorder and 12.8% of schizophrenia. 179 (13.3%) of 1342 ECT sessions were considered as failed. There was no statistically significant relationship between diagnosis for ECT and motor and EEG seizure times, spontaneous breathing, opening eyes, response to verbal comment times, hemodynamic parameters and complications. The seizure and recovery times were significantly shorter in the propofol group than ketamine and etomidate groups (p <0.05). The EEG seizure durations were longer in the etomidate group than in the propofol and ketamine group (respectively; p <0.001, p <0.05). Conclusion: In a conclusion, there were no effects of diagnosis for ECT on motor and EEG seizure times, spontaneous breathing, opening eyes, response to verbal comment times, hemodynamic parameters and complications. However anesthetics agents were affect all of these parameters.

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