Dergi Ara >>
Yıl:1999; Cilt: 2; Sayı: 3>> Özet
Klinik Psikiyatri Dergisi; 1999;2(3):167-171
Hızlı Sikluslu Bipolar Bozukluklar
N Yüksel
Gazi Üniversitesi, ANKARA
Hızlı sikluslu bipolar bozukluklar yılda dört veya daha fazla affektif atak olması ile tanımlanırlar. Depresyon dönemleri iki hafta, mani en az bir hafta ve hipomani ise dört gün süreli olmalıdır. Bazı olguların daha hızlı döngü göstermeleri olasıdır. Hızlı sikluslu bipolar bozuklukların etiyolojisinde sirkadiyen ritim değişiklikleri, melatonin salgısında değişiklikler, ısı ritminde değişimler ve hipotiroidi düşünülmektedir. Bu olguların tedavisinde geleneksel yöntemler genellikle etkin olmamaktadır. Uygun tedavi yöntemleri karbamazepin, valproik asit, fototerapi, tiroid hormonları ve kalsiyum kanal blokerleridir. Bu yöntemler birbiri ile veya lityumla birlikte kullanılabilir.
Rapid Cycling Bipolar Disorders
Rapid cycling bipolar disorder is defined as four or more affective episodes [year]ly. Conventionally recognized the duration of a depressive episode is two weeks. The duration of mania is at least one week and for hypomania it is four days. But it possible that some cases show much faster patterns. Circadian rhythm disregulations, melatonin secretion abnormalities, temperature rhythm disregulations and hypothyroidism might be involved in the pathogenesis of rapid cycling bipolar disorders. It is generally unresponsive to conventional interventions. The treatment modalities of this disorder involve carbamazepine, valproic acid alone or combination with lithium, phototherapy and other treatments, such as thyroid hormones and calcium channel blockers.

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