Introduction: In this study, we report the results of our experience of therapeutic plasma exchange (TPE) for neuroimmunologic disorders performed at our hospital over a seven-year period. Methods: We retrospectively reviewed the medical records of 91 patients (53 male, 38 female) who had been treated at our center with TPE. Results: 60 patients with Guillain-Barrè syndrome (GBS), 23 with myasthenia gravis (MG), 4 with chronic inflammatory demyelinating polyneuropathy (CIDP) and 1 patient each with polymyositis, septic encephalopathy, acute disseminated encephalomyelitis (ADEM) and Opsoclonus-Myoclonus syndrome (OMS) received TPE. 26.7% of GBS patient’s made complete recovery, 61.7% had partial recovery and 11.7% patients died due to respiratory failure. Despite our best efforts and effective TPE treatments, 13.4% of MG patients deceased, however, 78% had full recovery. Three patients with CIDP were discharged with full and 1 patient with partial recovery. The patient with ADEM had partial recovery with TPE at first, but deceased 2 months later due to pneumonia-related respiratory insufficiency. While, patient with polymyositis had slight-partial recovery, we obtained full recovery with TPE in septic encephalopathy and OMS patients. The side effects and complications of treatments with TPE, which included hypotension, hypocalcaemia and anemia, were mild and manageable. Conclusion: The improvement rates were encouraging and we concluded that significant benefit can be achieved with TPE for the treatment of neuroimmunological disorders.

Giris: Bu çalismada, terapötik plazma degisimi (TPD) ile tedavi ettigimiz nöroimmünolojik olgulara ait 7 yillik deneyimimizin sonuçlari rapor edilmistir. Yöntem: TPD uyguladigimiz 91 olgunun (53 erkek, 38 kadin) medikal kayitlari geriye dönük olarak incelenmistir. Bulgular: Tanisal olarak siniflandiginda, bu olgularin 60’inin Guillain- Barre sendromu (GBS), 23’ünün Miyastenia Gravis (MG), 4’ünün ise kronik inflammatuar demiyelinizan polinöropati (KIDP) tanisiyla TPD aldigi görülmüstür. Birer olguya ise, polimiyozit, septik ensefalopati, akut dissemine ensefalomiyelit (ADEM) ve Opsoklonus-Myoklonus sendromu (OMS) tanilariyla TPD uygulanmistir. GBS hastalarimizin %26,7’sinde tam düzelme, %61,7’sinde kismi düzelme izlenmis olup, disabilitesi yüksek %11,7 hasta solunum yetmezligi nedeniyle kaybedilmistir. MG’li hastalarin %13,4’ünde tedaviye ragmen ölüm, %78’inde tam klinik düzelme gözlenmistir. KIDP’li 4 hastamizin üçünde total, birinde kismi düzelme gözlenmis, ADEM’li olgumuz TPD ile önce kismen düzelmis ancak tedaviden 2 ay sonra aspirasyon pnömonisine bagli solunum yetmezligi nedeniyle kaybedilmis, polimiyozitli olgumuzda kismi, septik ensefalopati ve OMS’li hastalarimizda tam düzelme gözlenmistir. TPE uygulamasinda karsilastigimiz yan etkiler hipotansiyon, hipokalsemi ve anemi gibi hafif ve yönetilebilir düzeydedir. Sonuç: Çalismamizin sonuçlari otoimmün kökenli nörolojik hastaliklarda TPE tedavisinin etkili ve güvenilir bir yöntem oldugunu göstermektedir